ChemicalBook >> CAS DataBase List >>Regorafenib (Hydrochloride)
Regorafenib (Hydrochloride)
- CAS No.
- 835621-07-3
- Chemical Name:
- Regorafenib (Hydrochloride)
- Synonyms
- Regofini;Regafenib HCL;Regorafenib HC;Regorafenib HCl;Regafenib hydrochloride;BAY73-4506 hydrochloride;egorafenib (Hydrochloride);5-Diiodotyrosine Dihydrate;Regorafenib (Hydrochloride);Regorafenib HCl (BAY-73-4506)
- CBNumber:
- CB52624290
- Molecular Formula:
- C21H16Cl2F4N4O3
- Molecular Weight:
- 519.2763528
- MDL Number:
- MFCD22417053
- MOL File:
- 835621-07-3.mol
- MSDS File:
- SDS
Last updated:2024-03-29 13:51:46
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
Regorafenib (Hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0725 | Regorafenib(Hydrochloride) 99.58% | 835621-07-3 | 50mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A3750 | Regorafenibhydrochloride | 835621-07-3 | 10mg | $65 | 2021-12-16 | Buy |
| ChemScene | CS-0725 | Regorafenib(Hydrochloride) 99.58% | 835621-07-3 | 100mg | $80 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001550 | REGORAFENIB HYDROCHLORIDE 95.00% | 835621-07-3 | 5MG | $154 | 2021-12-16 | Buy |
| AK Scientific | 4001AH | Regorafenibhydrochloride | 835621-07-3 | 5mg | $186 | 2021-12-16 | Buy |
Regorafenib (Hydrochloride) Chemical Properties,Uses,Production
Uses
BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.
in vitro
Regorafenib potently inhibits VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with an IC50 of 3 nM. In HAoSMCs, regorafenib inhibits PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of 3 nMf. Regorafenib causes a concentration-dependent decrease in Hep3B cell growth, having an IC50 of 5 μM. Regorafenib subsequently increases the levels of phospho-c-Jun, a JNK target, but not total c-Jun in Hep3B cells.
in vivo
Regorafenib effectively inhibits growth of the Colo-205 xenografts in the dose range of 10-100 mg/kg reaching a TGI of 75% at day 14 at the 10 mg/kg dose. In the MDA-MB-231 model, regorafenib is highly efficacious at a dose as low as 3 mg/kg, resulting in a significant TGI of 81%, which increases to 93% at doses of 10 and 30 mg/kg, where tumor stasis is reached.
References
[1] Phan, Chiuyen et al. “Isomorphous Crystals Formed by the Similar Supramolecular Motifs in Sorafenib Hydrochloride and Regorafenib Hydrochloride Salts.” 2019. 0.
Regorafenib (Hydrochloride) Preparation Products And Raw materials
Global( 129)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 | jennysun@yzqyyykj.com | China | 64 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
View Lastest Price from Regorafenib (Hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-09 | Regorafenib (Hydrochloride)
835621-07-3
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-07-26 | Regorafenib (Hydrochloride)
835621-07-3
|
US $50.00 / kg | 1kg | 99.9% | 10000MT | Henan Bao Enluo International TradeCo.，LTD | |
 |
2023-03-25 | Regorafenib (Hydrochloride)
835621-07-3
|
US $100.00 / kg | 1kg | 98% | 20 tons | Hebei Duling International Trade Co. LTD |
-
- Regorafenib (Hydrochloride)
835621-07-3
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Regorafenib (Hydrochloride)
835621-07-3
- US $50.00 / kg
- 99.9%
- Henan Bao Enluo International TradeCo.，LTD
-
- Regorafenib (Hydrochloride)
835621-07-3
- US $100.00 / kg
- 98%
- Hebei Duling International Trade Co. LTD
835621-07-3(Regorafenib (Hydrochloride))Related Search:
4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide
(S,S')-3-METHYL-1-(2-PIPERIDINOPHENYL)BUTYLAMINE, N-ACETYL-GLUTAMATE SALT
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate
Regorafenib
Bortezomib
1of2
BAY73-4506 hydrochloride
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride
Regafenib HCL
Regafenib hydrochloride
2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, monohydrochloride
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride (1:1)
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydr
Regorafenib (Hydrochloride)
5-Diiodotyrosine Dihydrate
egorafenib (Hydrochloride)
Regorafenib HCl (BAY-73-4506)
Powder Regorafenib Hydrochloride CAS
Regorafenib Hydrochloride/BAY73-4506 hydrochloride
Regorafenib HC
4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride
Regorafenib HCl
Regofini
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1)
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-Pyridinecarboxamide hydrochloride (1:1)
4-4-4-Chloro-3-(trifluoromethyl)phenylaminocarbonylamino-3-fluorophenoxy-N-methylpyridin-2-carboxamide HCl
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrochloride
835621-07-3
C21H15ClF4N4O3HCl
C21H16Cl2F4N4O3
C21H15ClF4N4O3ClH