DBCO-PEG4-amine
- CAS No.
- 1255942-08-5
- Chemical Name:
- DBCO-PEG4-amine
- Synonyms
- DBCO-PEG4-NH2;DBCO-PEG4-amine;DBCO-NHCOPEG4-amine;DBCO-NH-PEG4-CH2CH2NH2;DBCO-NHCO-PEG4-amine TFA salt;Azadibenzocyclooctyne-PEG4-amine;DBCO-PEG4 amine (ADIBO-PEG4-amine);4,7,10,13-Tetraoxapentadecanamide, 15-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-;3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide
- CBNumber:
- CB53062466
- Molecular Formula:
- C29H37N3O6
- Molecular Weight:
- 523.62
- MDL Number:
- MFCD22380748
- MOL File:
- 1255942-08-5.mol
| Boiling point | 784.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 15.14±0.46(Predicted) |
| form | Solid |
| color | Yellow to Dark Yellow |
| Water Solubility | Soluble in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
DBCO-PEG4-amine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D194988 | DBCO-PEG4-amine | 1255942-08-5 | 1mg | $160 | 2021-12-16 | Buy |
| TRC | D194988 | DBCO-PEG4-amine | 1255942-08-5 | 2.5mg | $345 | 2021-12-16 | Buy |
| Chem-Impex | 35059 | DBCO-PEG-amine ≥ 95% (HPLC) | 1255942-08-5 | 25MG | $180 | 2021-12-16 | Buy |
| Chem-Impex | 35059 | DBCO-PEG-amine ≥ 95% (HPLC) | 1255942-08-5 | 100MG | $470 | 2021-12-16 | Buy |
| BroadPharm | BP-22292 | DBCO-NHCO-PEG4-amineTFAsalt 98% | 1255942-08-5 | 100mg | $495 | 2021-12-16 | Buy |
DBCO-PEG4-amine Chemical Properties,Uses,Production
Description
DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Biological Activity
DBCO-NHCO-PEG4-amine is a PROTAC linker and belongs to the PEG class. It is a cleavable ADC linker that can be used to link MMAE (HY-15162) to antibodies such as DBCO-VCpAB-MMAE and DBCO-TRX-MMAE, with EC50 for SKBR3 cells, respectively 280 nM and 22 nM).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9821 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
View Lastest Price from DBCO-PEG4-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-29 | DBCO-PEG4-amine
1255942-08-5
|
US $6.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2019-07-14 | DBCO-PEG4-amine
1255942-08-5
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- DBCO-PEG4-amine
1255942-08-5
- US $6.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- DBCO-PEG4-amine
1255942-08-5
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co