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ChemicalBook >> CAS DataBase List >>8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride

8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride

8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride Structure
8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride structure
CAS No.
1457983-33-3
Chemical Name:
8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride
Synonyms
G-749 hydrochloride;Denfivontinib hydrochloride;8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride;8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6h)-one hydrochloride
CBNumber:
CB53168432
Molecular Formula:
C25H26BrClN6O2
Molecular Weight:
557.86994
MDL Number:
MFCD23703605
MOL File:
1457983-33-3.mol
Last updated:2025-10-14 17:29:00
Request For Quotation

8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride Properties

storage temp. Store at 0-8 °C
FDA UNII 01ZQ25VJAL

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405

8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride Chemical Properties,Uses,Production

Uses

Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome[1].

References

[1] Kim DK, et al. Denfivontinib activates effector T-cells through NLRP3-inflammasome, yielding potent anticancer effects by combination with pembrolizumab. Mol Cancer Ther. 2024 Dec 5. DOI:10.1158/1535-7163.MCT-24-0501

8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
Twochem Co.Ltd 021-021-58111628 15800915896 sales@twochem.com China 304 55
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6555 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Twochem Co.Ltd 55
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58

View Lastest Price from 8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
G-749 hydrochloride pictures 2025-07-22 G-749 hydrochloride
1457983-33-3
 US $1970.00-2580.00 / mg 10g TargetMol Chemicals Inc.
8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride G-749 hydrochloride Denfivontinib hydrochloride 8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6h)-one hydrochloride 1457983-33-3