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ChemicalBook >> CAS DataBase List >>(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Structure
(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone structure
CAS No.
1883423-59-3
Chemical Name:
(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
Synonyms
CPD1540;MSC2530818;Cyclin dependent kinase,Inhibitor,CDK,MSC2530818,inhibit,MSC 2530818,MSC-2530818;(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone;[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone;Methanone, [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-
CBNumber:
CB53175818
Molecular Formula:
C18H17ClN4O
Molecular Weight:
340.81
MDL Number:
MFCD31382190
MOL File:
1883423-59-3.mol
Last updated:2023-06-08 09:03:01
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(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Properties

Boiling point 576.5±50.0 °C(Predicted)
Density 1.373±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml
form A crystalline solid
pka 9.65±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29669 MSC2530818 1883423-59-3 1mg $73 2024-03-01 Buy
Cayman Chemical 29669 MSC2530818 1883423-59-3 25mg $717 2024-03-01 Buy
Cayman Chemical 29669 MSC2530818 1883423-59-3 5mg $217 2024-03-01 Buy
Cayman Chemical 29669 MSC2530818 1883423-59-3 10mg $359 2024-03-01 Buy
American Custom Chemicals Corporation INB0005703 METHANONE, [(2S)-2-(4-CHLOROPHENYL)-1-PYRROLIDINYL](3-METHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)- 95.00% 1883423-59-3 5MG $459.97 2021-12-16 Buy
Product number Packaging Price Buy
29669 1mg $73 Buy
29669 25mg $717 Buy
29669 5mg $217 Buy
29669 10mg $359 Buy
INB0005703 5MG $459.97 Buy

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Chemical Properties,Uses,Production

Description

MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM). It is selective for Cdk8 over a panel of 264 kinases at 1 μM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Labnetwork lnc. 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58

1883423-59-3((S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone)Related Search:

(R)-2-(4-CHLOROPHENYL)PYRROLIDINE Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl- (2S)-2-(4-CHLOROPHENYL)PYRROLIDINE HCL (2R)-2-(4-CHLOROPHENYL)PYRROLIDINE HCL (S)-2-(4-CHLOROPHENYL)PYRROLIDINE
(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone MSC2530818 CPD1540 [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone Methanone, [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)- Cyclin dependent kinase,Inhibitor,CDK,MSC2530818,inhibit,MSC 2530818,MSC-2530818 1883423-59-3 API