PD 158780
- CAS No.
- Chemical Name:
- PD 158780
- Synonyms
- PD 158780;4-[(3-BROMOPHENYL)AMINO]-6-(METHYLAMINO)-PYRIDO[3,4-D]PYRIDIMINE
- CBNumber:
- CB5326060
- Molecular Formula:
- C14H12BrN5
- Molecular Weight:
- 330.18
- MDL Number:
- MFCD00942160
- MOL File:
- Mol file
PD 158780 Chemical Properties,Uses,Production
Uses
PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models.
Enzyme inhibitor
This photosensitive pyridopyrimidine (FW = 330.19 g/mol), known systematically as 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4- d]pyridimine, inhibits EPGFR (epidermal growth factor receptor) proteintyrosine kinase (IC50 = 8 pM). In addition, PD 158780 inhibits heregulinstimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB- 453 (IC50 = 52 nM) breast carcinomas.
PD 158780 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 158780 Suppliers
Global( 37)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9763 | 58 |
Supplier | Advantage |
---|---|
Shanghai Zeye Biotechnology Co., Ltd. | 58 |
4-[(3-BROMOPHENYL)AMINO]-6-(METHYLAMINO)-PYRIDO[3,4-D]PYRIDIMINE
PD 158780