ON-013100
- CAS No.
- 865783-95-5
- Chemical Name:
- ON-013100
- Synonyms
- ON-013100;UNII-J3I19I491A;ON-013100, 10 mM in DMSO;ON-013100;ON 013100;ON013100;(E)-2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenol;CDK,ON-013100,ON 013100,inhibit,Inhibitor,Cyclin dependent kinase,ON013100;Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-
- CBNumber:
- CB53339236
- Molecular Formula:
- C19H22O7S
- Molecular Weight:
- 394.44
- MDL Number:
- MFCD31540462
- MOL File:
- 865783-95-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| ON-013100 98.23% | CS-0066132 | 1mg | $90 |
| ON-013100 98.23% | CS-0066132 | 5mg | $140 |
| ON-013100 98.23% | CS-0066132 | 10mg | $220 |
| ON-013100 98.23% | CS-0066132 | 50mg | $620 |
| ON-013100 98.23% | CS-0066132 | 100mg | $920 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | J3I19I491A |
ON-013100 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066132 | ON-013100 98.23% | 865783-95-5 | 1mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0066132 | ON-013100 98.23% | 865783-95-5 | 5mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0066132 | ON-013100 98.23% | 865783-95-5 | 10mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-0066132 | ON-013100 98.23% | 865783-95-5 | 50mg | $620 | 2021-12-16 | Buy |
| ChemScene | CS-0066132 | ON-013100 98.23% | 865783-95-5 | 100mg | $920 | 2021-12-16 | Buy |
ON-013100 Chemical Properties,Uses,Production
Uses
ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.
IC 50
Cdk4/cyclin D1
References
[1] Cho SY, et al. Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal. 2013 Mar 5;75:138-44. DOI:10.1016/j.jpba.2012.11.022
[2] Park IW, et al. Evaluation of novel cell cycle inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. DOI:10.1038/sj.onc.1210350
[3] Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.
ON-013100 Preparation Products And Raw materials
Raw materials
Preparation Products
ON-013100 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7778 | 56 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1844 | 58 | |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
