S-Facinicline
- CAS No.
- 677305-02-1
- Chemical Name:
- S-Facinicline
- Synonyms
- RG3487;S-Facinicline;RG3487 hydrochloride;Facinicline hydrochloride;Facinicline hydrochloride, 10 mM in DMSO;Inhibitor,nAChR,serotonin 3 receptor,Nicotinic acetylcholine receptors,Serotonin Receptor,5-HT Receptor,inhibit,recognition,5-hydroxytryptamine Receptor,Facinicline,Facinicline hydrochloride,receptor,RG-3487,memory,RG 3487,nicotinic
- CBNumber:
- CB53379708
- Molecular Formula:
- C15H19ClN4O
- Molecular Weight:
- 306.79056
- MDL Number:
- MFCD32690070
- MOL File:
- 677305-02-1.mol
| Product description | Number | Pack Size | Price |
| Facinicline(hydrochloride) 99.93% | CS-0081613 | 5mg | $300 |
| Facinicline(hydrochloride) 99.93% | CS-0081613 | 10mg | $500 |
| Facinicline(hydrochloride) 99.93% | CS-0081613 | 50mg | $1400 |
| Facinicline(hydrochloride) 99.93% | CS-0081613 | 100mg | $2200 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO: 125 mg/mL (407.44 mM); Methanol: 25 mg/mL (81.49 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | O6J463N18M |
S-Facinicline price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0081613 | Facinicline(hydrochloride) 99.93% | 677305-02-1 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0081613 | Facinicline(hydrochloride) 99.93% | 677305-02-1 | 10mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-0081613 | Facinicline(hydrochloride) 99.93% | 677305-02-1 | 50mg | $1400 | 2021-12-16 | Buy |
| ChemScene | CS-0081613 | Facinicline(hydrochloride) 99.93% | 677305-02-1 | 100mg | $2200 | 2021-12-16 | Buy |
S-Facinicline Chemical Properties,Uses,Production
Uses
Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].
Biological Activity
Facinicline hydrochloride (RG3487 hydrochloride) is an orally active partial agonist of the nicotinic α7 receptor with a Ki of 6 nM for human nAChR. It (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride has a Ki value of 1.2 nM for the 5-HT3 receptor (antagonist).
in vitro
Facinicline (RG3487) activates human α7 nAChRs with an EC 50 of 0.8 μM (oocytes) and 7.7 μM (QM7 cells).
It (RG3487) exhibits antagonist properties at the serotonin 3 receptor (IC 50 2.8 nM (oocytes), 32.7 nM (N1E-115 cells)).
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in vivo
Facinicline (RG3487) improves object recognition memory in rats after acute [minimally effective dose (MED) 1.0 mg/kg po] or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range.
RG3487 (0.1–10 mg/kg po) selectively enhances object recognition memory.
| Animal Model: | Male Sprague-Dawley rats. |
| Dosage: | 0.1-10 mg/kg (Pharmacokinetic Analysis ). |
| Administration: | Orally. |
| The mean C max was typically observed between 0.5 and 4 h. |
target
| 5-HT 3 Receptor 1.2 nM (Ki) | α7 < span> 6 nM (Ki) |
IC 50
5-HT3 Receptor: 1.2 nM (Ki); α7: 6 nM (Ki)
References
[1] Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336(1):242-53. DOI:10.1124/jpet.110.171892
S-Facinicline Preparation Products And Raw materials
Raw materials
Preparation Products
S-Facinicline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3767 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Xenoah Pharmaceutical Inc. | 0512-6956-1983 | info@xenoah.com | China | 296 | 58 |
| SuZhou Medinoah Co.,LTD. | 0512-69561983 13914027025 | zhang_q@medinoah.com | China | 3809 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
