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Isosilybin

Isosilybin
Isosilybin structure
CAS No.
72581-71-6
Chemical Name:
Isosilybin
Synonyms
Q-100795;Isosilybin;Isosilybinin;ISOSILIBININ;indissolubly;Isosilybin,ISB;ISOSILYBIN hplc;Isosilybin USP/EP/BP;Isosilybin (A+B) mixture;Isosilybin (Isosilybinin)
CBNumber:
CB5359479
Molecular Formula:
C25H22O10
Formula Weight:
482.44
MOL File:
72581-71-6.mol

Isosilybin Properties

Boiling point:
793.0±60.0 °C(Predicted)
Density 
1.527±0.06 g/cm3(Predicted)
pka
7.39±0.60(Predicted)

Isosilybin price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24913 Isosilybin ≥95% 72581-71-6 1mg $199 2021-12-16 Buy
Cayman Chemical 24913 Isosilybin ≥95% 72581-71-6 5mg $896 2021-12-16 Buy
TRC I901000 Isosilybin 72581-71-6 1mg $235 2021-12-16 Buy
Usbiological 300505 Isosilybin 72581-71-6 10mg $448 2021-12-16 Buy
Usbiological 280565 Isosilybin 72581-71-6 5mg $595 2021-12-16 Buy

Isosilybin Chemical Properties,Uses,Production

Description

Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

Uses

Useful in the treatment of liver disease.

Uses

Isosilybin is useful in the treatment of liver disease

Definition

ChEBI: A flavonolignan isolated from Silybum marianum.

Isosilybin Preparation Products And Raw materials

Raw materials

Preparation Products


Isosilybin Suppliers

Global( 139)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Chengdu Greenpure Biopharma CO.,Ltd
18283602253
jancyzheng@gcgreenpure.com CHINA 1257 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com China 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Neostar United (Changzhou) Industrial Co., Ltd.
+0086-519-85557386
+0086-519-85557389 marketing1@neostarunited.com CHINA 4135 58

View Lastest Price from Isosilybin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-02 Isosilybin
72581-71-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2020-08-13 Isosilybin
72581-71-6
US $0.00 / mg 20mg ≥98%(HPLC) 100 g Shanghai Standard Technology Co., Ltd.
2020-01-01 Isosilybin
72581-71-6
US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

72581-71-6(Isosilybin)Related Search:


  • ISOSILIBININ
  • ISOSILYBIN(PRIMARY STANDARD)
  • Isosilybinin
  • Isosilybin (Isosilybinin)
  • (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • ISOSILYBIN hplc
  • Isosilybin (A+B) mixture
  • -(2,3-Dihydro-2-(4-hydroxy-3-Methoxyphenyl)-3-(hydroxyMethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • Isosilybin
  • 4H-1-Benzopyran-4-one,2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-
  • Q-100795
  • Isosilybin (Mixture of Diastereomers)
  • Isosilybin,ISB
  • Isosilybin USP/EP/BP
  • indissolubly
  • 72581-71-6
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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