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1,5-ISOQUINOLINEDIOL

1,5-ISOQUINOLINEDIOL structure

CAS No.: 5154-02-9

Chemical Name:: 1,5-ISOQUINOLINEDIOL

Synonyms: DHQ;DIQ;NSC 65585;1,5-ISOQUINOLINEDIOL;isoquinoline-1,5-diol;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-DIHYDROXYISOQUINOLINE;1,5-Isoquinolinediol ,97%

CBNumber:: CB5360303

Molecular Formula:: C9H7NO2

Molecular Weight:: 161.16

MDL Number:: MFCD00006900

MOL File:: 5154-02-9.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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1,5-ISOQUINOLINEDIOL Properties

Melting point	270-275 °C
Boiling point	287.44°C (rough estimate)
Density	1.2480 (rough estimate)
refractive index	1.5050 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO: >36 mg/mL
form	solid
pka	8.52±0.20(Predicted)
color	off-white
CAS DataBase Reference	5154-02-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HS Code

29337900

NFPA 704

	0
2		0

1,5-ISOQUINOLINEDIOL price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	419800	PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.	5154-02-9	5MG	$96.4	2023-01-07	Buy
Sigma-Aldrich	I138	1,5-Isoquinolinediol ≥98% (HPLC), powder	5154-02-9	5MG	$59.9	2022-05-15	Buy
Cayman Chemical	14438	1,5-Isoquinolinediol ≥98%	5154-02-9	5mg	$36	2024-03-01	Buy
Cayman Chemical	14438	1,5-Isoquinolinediol ≥98%	5154-02-9	25mg	$78	2024-03-01	Buy
Cayman Chemical	14438	1,5-Isoquinolinediol ≥98%	5154-02-9	100mg	$207	2024-03-01	Buy

Product number	Packaging	Price	Buy
419800	5MG	$96.4	Buy
I138	5MG	$59.9	Buy
14438	5mg	$36	Buy
14438	25mg	$78	Buy
14438	100mg	$207	Buy

1,5-ISOQUINOLINEDIOL Chemical Properties,Uses,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

Reagent used in the preparation of PARP inhibitor.

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

1,5-ISOQUINOLINEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate

1,5-ISOQUINOLINEDIOL Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	13854	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
WinWin Chemical CO., Limited	58
Wuhan Fortuna Chemical Co., Ltd	58
Henan Alfa Chemical Co., Ltd	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58

View Lastest Price from 1,5-ISOQUINOLINEDIOL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-04-08	1,5-Isoquinolinediol 5154-02-9	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD

1,5-Isoquinolinediol
5154-02-9
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

5154-02-9(1,5-ISOQUINOLINEDIOL)Related Search:

1,5-ISOQUINOLINEDIOL 7-isoquinolinediol,1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-h 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-Tetrahydro-1-methyl-6,7-Isoquinolinediol 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methyl-6,7-isoquinolinediol 5-Hydroxyisoquinoline

Isoquinoline Isocarbostyril 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE 98% 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol Tretoquinol

(S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride 5-METHOXY-2H-ISOQUINOLIN-1-ONE 6,7-Isoquinolinediol, 1-propyl- (9CI) d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI)

6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI) 3,4-Dihydro-6,7-isoquinolinediol. Tretoquinol hydrochloride

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1,5-ISOQUINOLINEDIOL 1,5-DIHYDROXYISOQUINOLINE 5-HYDROXYISOCARBOSTYRIL 5-HYDROXY-1(2H)-ISOQUINOLINE 5-HYDROXY-1(2H)-ISOQUINOLINONE 1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE) 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ 5-Hydroxyisoquinoline-1(2H)-one DHQ 1,5-Isoquinolinediol,98% 1,5-dihydroxy-1(2H)-isoquinoline 1,5-Isoquinolinediol ,97% isoquinoline-1,5-diol 5-hydroxyisoquinolin-1(2H)-one 5-Hydroxy-isoquinolinone NSC 65585 DIQ 1(2H)-Isoquinolinone, 5-hydroxy- 5-hydroxy-1,2-dihydroisoquinolin-1-one Isoquinolinediol, 1,5- - NSC 65585 PARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,NADPH,1,5-Isoquinolinediol,Inhibitor,1,5Isoquinolinediol,oxidase,poly ADP ribose polymerase 5154-02-9 PARP Regulators PARP BioChemical Apoptosis and Cell Cycle Cell Signaling and Neuroscience Cell Biology Aromatics Inhibitors