Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem
- CAS No.
- Chemical Name:
- Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem
- Synonyms
- Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem
- CBNumber:
- CB54817827
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable, potent, fast-acting, and selective inhibitor of prolyl oligopeptidase (PREP) (Ki = 23 pM). Reported to cross the blood-brain barrier. Inhibits about 85% PREP activity within 10 minutes of administration and exhibits a half-life of about 4.8 hours. Exhibits higher lipophilicity that increases its penetration across biological membranes in vivo. Maximum plasma and brain levels are achieved within 10 minutes following its i.p. administration. Shown to block oxidative-stress induced α-synuclein aggregation and clearance in cellular and animal models of Parkinson′s disease. Also shown to improve cognitive performance in young rats (1-5 mg/kg) in a dose-dependent manner.
Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem