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JH-XI-10-02

JH-XI-10-02 Structure
JH-XI-10-02 structure
CAS No.
2209085-22-1
Chemical Name:
JH-XI-10-02
Synonyms
JH-X1-10-02;JH-XI-10-02;4,7,10,13-Tetraoxapentadecanamide, 15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-;N-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-1-(isoquinolin-7-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide
CBNumber:
CB54844926
Molecular Formula:
C53H69N5O9
Molecular Weight:
920.16
MDL Number:
MFCD31813655
MOL File:
2209085-22-1.mol
Last updated:2025-12-03 18:03:33
Product description Number Pack Size Price
JH-XI-10-02 98.18% CS-0042316 1mg $580
JH-XI-10-02 98.18% CS-0042316 5mg $1450
JH-XI-10-02 98.18% CS-0042316 10mg $2350
JH-XI-10-02 98.18% CS-0042316 25mg $4500
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JH-XI-10-02 Properties

Density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (108.68 mM; Need ultrasonic)
pka 10.74±0.40(Predicted)
form Solid
color Yellow to brown

JH-XI-10-02 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0042316 JH-XI-10-02 98.18% 2209085-22-1 1mg $580 2021-12-16 Buy
ChemScene CS-0042316 JH-XI-10-02 98.18% 2209085-22-1 5mg $1450 2021-12-16 Buy
ChemScene CS-0042316 JH-XI-10-02 98.18% 2209085-22-1 10mg $2350 2021-12-16 Buy
ChemScene CS-0042316 JH-XI-10-02 98.18% 2209085-22-1 25mg $4500 2021-12-16 Buy
Product number Packaging Price Buy
CS-0042316 1mg $580 Buy
CS-0042316 5mg $1450 Buy
CS-0042316 10mg $2350 Buy
CS-0042316 25mg $4500 Buy

JH-XI-10-02 Chemical Properties,Uses,Production

Uses

JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].

Biological Activity

JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1]. JH-XI-10-02, a bivalent small molecule degrader, recruits the E3 ligase CRL4Cereblon to promote the ubiquitination and proteosomal degradation of CDK8[1]. JH-XI-10-02 (1 μM) induces partial degradation of CDK8 in Jurkat cells upon treatment for 6 h. JH-XI-10-02 (1 μM) induces significant degradation of CDK8 after treatment for 24 h[1]. JH-XI-10-02 induces degradation of CDK8 at 5 μM in WT Molt4 cells, no degradation in CRBN null Molt4 cells at any concentration (0.1-5 μM) in WT Molt4 cells and Molt4 cells where CRBN had been subject to CRISPER/CAS9-mediated deletion for 24 h[1].

IC 50

CDK8: 159 nM (IC50); Cereblon

storage

Store at -20°C

References

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545.

JH-XI-10-02 Preparation Products And Raw materials

Raw materials

Preparation Products

JH-XI-10-02 Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1616 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4989 58
cjbscvictory 13348960310 3003867561@qq.com China 10503 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24961 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
cjbscvictory 58
TargetMol Chemicals Inc. 58

View Lastest Price from JH-XI-10-02 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JH-XI-10-02 pictures 2025-12-03 JH-XI-10-02
2209085-22-1
 US $1980.00 / mg 10g TargetMol Chemicals Inc.
  • JH-XI-10-02 pictures
  • JH-XI-10-02
    2209085-22-1
  • US $1980.00 / mg
  • TargetMol Chemicals Inc.
4,7,10,13-Tetraoxapentadecanamide, 15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl- JH-XI-10-02 JH-X1-10-02 N-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-1-(isoquinolin-7-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide 2209085-22-1 C53H69N5O9