ChemicalBook >> CAS DataBase List >>4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol structure

CAS No.: 1202764-53-1

Chemical Name:: 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

Synonyms: B022;B022,B-022;4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol;2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-

CBNumber:: CB55582861

Molecular Formula:: C19H16ClN5OS

Molecular Weight:: 397.88

MDL Number:: MFCD32645350

MOL File:: 1202764-53-1.mol

Last updated:2023-05-21 10:59:17

Request For Quotation

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Properties

Boiling point	644.4±65.0 °C(Predicted)
Density	1.53±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 250 mg/mL (628.33 mM)
pka	10.71±0.29(Predicted)

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0078192	B022 98.10%	1202764-53-1	5mg	$205	2021-12-16	Buy
ChemScene	CS-0078192	B022 98.10%	1202764-53-1	10mg	$350	2021-12-16	Buy
ChemScene	CS-0078192	B022 98.10%	1202764-53-1	50mg	$1250	2021-12-16	Buy
ChemScene	CS-0078192	B022 98.10%	1202764-53-1	100mg	$2200	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0078192	5mg	$205	Buy
CS-0078192	10mg	$350	Buy
CS-0078192	50mg	$1250	Buy
CS-0078192	100mg	$2200	Buy

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Chemical Properties,Uses,Production

Biological Activity

B022 is a potent and selective NF-κB-inducible kinase (NIK) inhibitor with Ki of 4.2 nM. B022 protects the liver from inflammation, oxidative stress and damage caused by toxins.

in vitro

B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner.
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.

Western Blot Analysis

Cell Line:	Hepa1 cells
Concentration:	0 μM, 0.5 μM, 5 μM
Incubation Time:	12 hours
Result:	Suppressed NIK-induced p52 formation in a dose-dependent manner.	td>

RT-PCR

Cell Line:	Hepa1 cells
Concentration:	0 μM, 0.5 μM, 5 μM
Incubation Time:	12 hours
Result:	Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.

< /span>

in vivo

B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses. < /p>

< tr>

Animal Model:	STOP-NIK male mice (8 weeks) infected with Ad-cre
Dosage:	30 mg/kg
Administration:	Intravenous injection; twice a day; for 10 days
Result:	Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.

target

Ki: 4.2 nM (NF-κB-inducing kinase (NIK))

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3421	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
Heze Development Zone chuangli Chemical Co., Ltd.	+86-530-529 6766，+86-15666160102 15666160102	info@chuangli-chem.com	China	877	55
Wuhan Anruike Pharmaceutical Technology Co., Ltd.	18572841024	28128719@qq.com	China	1985	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai EFE Biological Technology Co., Ltd.	58
ShangHai Biochempartner Co.,Ltd	62
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Heze Development Zone chuangli Chemical Co., Ltd.	55
Wuhan Anruike Pharmaceutical Technology Co., Ltd.	58

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol B022 2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl- B022,B-022 1202764-53-1