1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-
![1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Structure](CAS/20200515/GIF/1093412-18-0.gif)
- CAS No.
- 1093412-18-0
- Chemical Name:
- 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-
- Synonyms
- FFPM;Roflupram;Roflupram >=98% (HPLC);1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-
- CBNumber:
- CB55875992
- Molecular Formula:
- C16H20F2O4
- Molecular Weight:
- 314.32
- MDL Number:
- MFCD31697733
- MOL File:
- 1093412-18-0.mol
| Product description | Number | Pack Size | Price |
| Roflupram ≥98% (HPLC) | SML2106 | 5MG | $91.8 |
| Roflupram ≥98% (HPLC) | SML2106 | 25MG | $371 |
1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- price
1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Chemical Properties,Uses,Production
Uses
Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
Biological Activity
Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
IC 50
PDE4: 26.2 nM (IC50)
References
[1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392.
1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 1010 | 58 |
| Block Chemical Technology (Shanghai) Co., Ltd. | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 10034 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4989 | 58 |
| Block Chemical Technology (Shanghai) Co., Ltd. | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 11318 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 2998 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
