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2,4-DICHLORO-3-NITRO-QUINOLINE

2,4-DICHLORO-3-NITRO-QUINOLINE structure

CAS No.: 132521-66-5

Chemical Name:: 2,4-DICHLORO-3-NITRO-QUINOLINE

Synonyms: Zinc02551827;AURORA KA-4144;2,4-Dichlor-3-nitro-chinolin;3-NITRO-2,4-DICHLORO QUINOLINE;2,4-DICHLORO-3-NITRO-QUINOLINE;Quinoline, 2,4-dichloro-3-nitro-;2,4-Dichloro-3-nitroquinoline 95%;Benzaldehyde,4-methoxy-4-(phenylmethoxy)-;2,4-DICHLORO-3-NITRO-QUINOLINE ISO 9001：2015 REACH

CBNumber:: CB5773772

Molecular Formula:: C9H4Cl2N2O2

Molecular Weight:: 243.05

MDL Number:: MFCD05666285

MOL File:: 132521-66-5.mol

MSDS File:: SDS

Last updated:2026-07-09 12:03:46

Product description	Number	Pack Size	Price
2,4-Dichloro-3-nitroquinoline	TRC-D439308-50MG	50mg	$168
2,4-Dichloro-3-nitroquinoline	TRC-D439308-10MG	10mg	$70
2,4-Dichloro-3-nitroquinoline	TRC-D439308-100MG	100mg	$261
2,4-Dichloro-3-nitroquinoline	FD159596	5g	$324.5
2,4-Dichloro-3-nitroquinoline	FD159596	10g	$519.2
More product size

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2,4-DICHLORO-3-NITRO-QUINOLINE Properties

Melting point	102 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
Boiling point	359.7±37.0 °C(Predicted)
Density	1.593±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-4.98±0.50(Predicted)
color	White to Off-White
InChI	InChI=1S/C9H4Cl2N2O2/c10-7-5-3-1-2-4-6(5)12-9(11)8(7)13(14)15/h1-4H
InChIKey	RSFJVCHKGRUCIC-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(Cl)=C([N+]([O-])=O)C=1Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933499090

2,4-DICHLORO-3-NITRO-QUINOLINE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-D439308-50MG	2,4-Dichloro-3-nitroquinoline	132521-66-5	50mg	$168	2026-06-03	Buy
TRC	TRC-D439308-10MG	2,4-Dichloro-3-nitroquinoline	132521-66-5	10mg	$70	2026-06-03	Buy
TRC	TRC-D439308-100MG	2,4-Dichloro-3-nitroquinoline	132521-66-5	100mg	$261	2026-06-03	Buy
Biosynth	FD159596	2,4-Dichloro-3-nitroquinoline	132521-66-5	5g	$324.5	2026-06-04	Buy
Biosynth	FD159596	2,4-Dichloro-3-nitroquinoline	132521-66-5	10g	$519.2	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-D439308-50MG	50mg	$168	Buy
TRC-D439308-10MG	10mg	$70	Buy
TRC-D439308-100MG	100mg	$261	Buy
FD159596	5g	$324.5	Buy
FD159596	10g	$519.2	Buy

2,4-DICHLORO-3-NITRO-QUINOLINE Chemical Properties,Uses,Production

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Description

2,4-Dichloro-3-nitroquinoline is a chemotherapeutic drug that belongs to the class of epidermal growth factor receptor (EGFR) inhibitors. This agent has anticancer activity against cells in the G1 phase of the cell cycle and may also have some antiproliferative effects on tumor cells. 2,4-Dichloro-3-nitroquinoline binds to EGFR and inhibits the binding of epidermal growth factor (EGF) to its receptor. This binding causes the activation of downstream signaling pathways that regulate cell proliferation.

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Synthesis

15151-57-2

132521-66-5

(2) Synthesis of 2,4-dichloro-3-nitroquinoline: In a 20 mL round-bottomed flask, 3-nitroquinoline-2,4-diol (1 g, 4.85 mmol), phosphorus trichloride (appropriate amount) and N,N-dimethylaniline (0.19 mL) were added sequentially. The reaction mixture was stirred at 90 °C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water, and stirring was continued for 0.5 hours. The precipitate precipitated was collected by filtration and dried under vacuum overnight. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1, v/v) to give 0.7 g of white solid product in 59.4% yield.

References

[1] Medicinal Chemistry Research, 2014, vol. 23, # 6, p. 2964 - 2975
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 11, p. 4450 - 4465
[3] Patent: WO2013/67597, 2013, A1. Location in patent: Page/Page column 78
[4] Patent: WO2018/191746, 2018, A1. Location in patent: Paragraph 0391
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 921 - 926

2,4-DICHLORO-3-NITRO-QUINOLINE Preparation Products And Raw materials

Raw materials

2,4-DIHYDROXY-3-NITROQUINOLINE

Preparation Products

2-Chloro-N4-(2-methypropyl)-3,4-quinolinediamine

2,4-DICHLORO-3-NITRO-QUINOLINE Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Zhonghan Chemical Technology Co., LTD.	+undefined15066662237	3281004549@qq.com	China	291	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4017	58
Dideu Industries Group Limited	+86-86-15536356810 +8617392712697	1022@dideu.com	China	29107	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58

Supplier	Advantage
Jinan Zhonghan Chemical Technology Co., LTD.	58
career henan chemical co	58
Accela ChemBio Inc.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Dideu Industries Group Limited	58
Labnetwork lnc.	58
sgtlifesciences pvt ltd	58
Alfa Chemistry	58

View Lastest Price from 2,4-DICHLORO-3-NITRO-QUINOLINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-08	2,4-dichloro-3-nitroquinoline 132521-66-5		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-06-30	2,4-DICHLORO-3-NITRO-QUINOLINE 132521-66-5		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	2,4-DICHLORO-3-NITRO-QUINOLINE 132521-66-5	$1.10	1g	99.00%	5760-20-3	Dideu Industries Group Limited

2,4-dichloro-3-nitroquinoline
132521-66-5
98%
Shaanxi Dideu New Materials Co. Ltd

2,4-DICHLORO-3-NITRO-QUINOLINE
132521-66-5
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2,4-DICHLORO-3-NITRO-QUINOLINE
132521-66-5
$1.10
99.00%
Dideu Industries Group Limited

2,4-DICHLORO-3-NITRO-QUINOLINE Spectrum

2,4-DICHLORO-3-NITRO-QUINOLINE(132521-66-5)¹HNMR 2,4-DICHLORO-3-NITRO-QUINOLINE(132521-66-5)FT-IR

132521-66-5(2,4-DICHLORO-3-NITRO-QUINOLINE)Related Search:

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AURORA KA-4144 2,4-DICHLORO-3-NITRO-QUINOLINE 3-NITRO-2,4-DICHLORO QUINOLINE Zinc02551827 2,4-Dichlor-3-nitro-chinolin 2,4-Dichloro-3-nitroquinoline 95% Quinoline, 2,4-dichloro-3-nitro- 2,4-DICHLORO-3-NITRO-QUINOLINE ISO 9001：2015 REACH Benzaldehyde,4-methoxy-4-(phenylmethoxy)- 132521-66-5