PP2A1
- CAS No.
- Chemical Name:
- PP2A1
- Synonyms
- PP2A1;PPA2A1;EC 3.1.3.16;PROTEIN PHOSPHATASE 2A1;PROTEIN PHOSPHATASE 2A1, BOVINE;PROTEIN PHOSPHATASE 2A1, BOVINE KIDNEY;Protein Phosphatase 2A1 from rabbit muscle
- CBNumber:
- CB5775514
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00241719
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Safety Statements | 23-24/25 |
|---|---|
| WGK Germany | 1 |
PP2A1 Chemical Properties,Uses,Production
Uses
Protein phosphatase 2A1 has been used to treat human fibroblast cells prior to western blot analysis.
General Description
Protein Phosphatase 2A1 (PP2A1) belongs to the PP2A family and comprises trimeric A, B and C subunits. PPA2 enzymes are serine/threonine phosphatases and exist as several isoforms.
Biochem/physiol Actions
Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with microtubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 (PP2A1) binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity. PP2A1 is implicated as a growth suppressor and is associated with dysregulation in cancer. It also regulates cell cycle, RNA splicing differentiation, and signal transduction. PP2A dysfunction is correlated to the tau protein deregulation in Alzheimer′s disease pathophysiology. Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dysregulation in cancer.
PP2A1 Preparation Products And Raw materials
Raw materials
Preparation Products
PP2A1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
| VWR International | -- | solutions@vwr.com | United Kingdom | 6554 | 82 |
| Nacalai Tesque, Inc. | -- | info-tech@nacalai.co.jp | Japan | 6048 | 75 |
| BIOMOL INTERNATIONAL, LP | -- | info@biomol.com | United States | 1503 | 77 |
| Upstate | -- | info@upstate.com | United States | 876 | 76 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| EMD Biosciences, Inc. | 66 |
| VWR International | 82 |
| Nacalai Tesque, Inc. | 75 |
| BIOMOL INTERNATIONAL, LP | 77 |
| Upstate | 76 |