LY 379268
- CAS No.
- 191471-52-0
- Chemical Name:
- LY 379268
- Synonyms
- CS-1087;LY397268;LY 379268;(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid;2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-
- CBNumber:
- CB5841046
- Molecular Formula:
- C7H9NO5
- Molecular Weight:
- 187.15
- MDL Number:
- MFCD11100365
- MOL File:
- 191471-52-0.mol
| Boiling point | 413.9±45.0 °C(Predicted) |
|---|---|
| Density | 1.716±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble in H2O or NaOH |
| form | solid |
| pka | 1.81±0.40(Predicted) |
| color | White |
| Water Solubility | Soluble to 20 mM in water and to 100 mM in 1eq. NaOH |
| FDA UNII | S96JF4J697 |
LY 379268 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15351 | LY379268 ≥99% | 191471-52-0 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 15351 | LY379268 ≥99% | 191471-52-0 | 5mg | $200 | 2024-03-01 | Buy |
| Cayman Chemical | 15351 | LY379268 ≥99% | 191471-52-0 | 10mg | $326 | 2024-03-01 | Buy |
| Tocris | 2453 | LY379268 ≥99%(HPLC) | 191471-52-0 | 10 | $392 | 2021-12-16 | Buy |
| Tocris | 2453 | LY379268 ≥99%(HPLC) | 191471-52-0 | 50 | $1649 | 2021-12-16 | Buy |
LY 379268 Chemical Properties,Uses,Production
Uses
LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates.
Definition
ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid.
Biological Activity
Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active.
storage
Store at +4°C
LY 379268 Preparation Products And Raw materials
Raw materials
Preparation Products
LY 379268 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2867 | 52 | |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |