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LY 294002 HYDROCHLORIDE

LY 294002 HYDROCHLORIDE structure

CAS No.: 154447-36-6

Chemical Name:: LY 294002 HYDROCHLORIDE

Synonyms: YX;SF 1101;CS-1859;LY240092;LY 294002;NSC 697286;LY294002HCl;LY294002/PI3K;LY 294002, 99+%;PI3K inhibitor kit

CBNumber:: CB1242450

Molecular Formula:: C19H17NO3

Molecular Weight:: 307.34

MDL Number:: MFCD01530034

MOL File:: 154447-36-6.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:15

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LY 294002 HYDROCHLORIDE Properties

Melting point	183-185℃
Boiling point	494.6±45.0 °C(Predicted)
Density	1.266
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: >5 mg/mL
form	solid
pka	0.55±0.20(Predicted)
color	white to off-white
Water Solubility	Soluble in DMSO at 5mg/ml. Insoluble in water
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey	CZQHHVNHHHRRDU-UHFFFAOYSA-N
CAS DataBase Reference	154447-36-6
FDA UNII	31M2U1DVID

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H320-H361-H370-H372-H336-H402
Precautionary statements	P501-P273-P260-P270-P202-P201-P271-P264-P280-P337+P313-P305+P351+P338-P308+P311-P301+P312+P330-P304+P340+P312-P403+P233-P405
Safety Statements	24-25
WGK Germany	3
HS Code	29349990

LY 294002 HYDROCHLORIDE price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	440202	LY 294002	154447-36-6	5mg	$216	2024-03-01	Buy
Sigma-Aldrich	440202	LY 294002	154447-36-6	10mg	$303	2024-03-01	Buy
TCI Chemical	M2410	2-Morpholino-8-phenylchromone >98.0%(HPLC)	154447-36-6	25mg	$243	2024-03-01	Buy
Alfa Aesar	J67289	LY 294002, 98%	154447-36-6	5mg	$89.7	2023-06-20	Buy
Alfa Aesar	J67289	LY 294002, 98%	154447-36-6	10mg	$117	2021-12-16	Buy

Product number	Packaging	Price	Buy
440202	5mg	$216	Buy
440202	10mg	$303	Buy
M2410	25mg	$243	Buy
J67289	5mg	$89.7	Buy
J67289	10mg	$117	Buy

LY 294002 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC₅₀ of 1.4 μM.

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

Uses

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Uses

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Uses

A potent blocker of PI 3-kinase/Akt signaling.

Definition

ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

target

p110α

References

1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241

LY 294002 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

4H-1-Benzopyran-4-one, 8-hydroxy-2-(4-morpholinyl)- 1-(2-hydroxybiphenyl-3-yl)-3-morpholinopropane-1,3-dione N-Acetylmorpholine Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester methyl 2-hydroxy-3-phenyl-benzoate

methyl 2,3-dihydroxybenzoate Methyl 3-methoxysalicylate 2,3-Dihydroxybenzoic acid 3-Methoxysalicylic acid Phenylboronic acid

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Preparation Products

LY 294002 HYDROCHLORIDE Suppliers

Global( 292)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from LY 294002 HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	LY 294002 HYDROCHLORIDE 154447-36-6	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

LY 294002 HYDROCHLORIDE
154447-36-6
US $2.00 / kg
99%
Career Henan Chemical Co

LY 294002 HYDROCHLORIDE Spectrum

LY 294002 HYDROCHLORIDE(154447-36-6)¹HNMR

154447-36-6(LY 294002 HYDROCHLORIDE)Related Search:

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LY 294002 LY 294002 HYDROCHLORIDE 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE LY 294002, 99+% LY294002HCl 2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride LY-294002;LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE 8-Phenyl-2-(morpholin-4-yl)chromen-4-one 2-[4-Morpholinyl]-8-phenyl-1[4H]-benzopyran-4-on NSC 697286 SF 1101 2-Morpholino-8-phenyl-4H-chroMen-4-one 2-Morpholino-8-phenylchroMone 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 294002 LY 294002 8-Phenyl-2-(morpholin-4-yl)chromen-4-one LY294002 (HCI Salt) LY240092 LY294002, NSC 697286 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran InSolution? LY 294002 CS-1859 LY294002 (HCl Salt) 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ON InSolution LY 294002 - CAS 154447-36-6 - Calbiochem LY 294002 - CAS 154447-36-6 - Calbiochem 2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-on PI3K inhibitor kit NSC 697286; SF 1101; LY 294002; LY-294002 Morpholino phenylchromone 2-Morpholino-8-phenylchromone> 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- YX LY294002/PI3K LY 294002 HYDROCHLORIDE USP/EP/BP LY 294002, Free Base LY 294002 (DMSO solution) 154447-36-6 C19H18ClNO3HCl C19H17O3N Specific cell permeable phosphatidylinositol 3-kinase inhibitor. Cell Biology Cell Signaling and Neuroscience BioChemical Kinase/Phosphatase Biology Phosphatidylinositol 3-kinase (PI3K) Serine/Threonine Kinase Inhibitors Inhibitors Inhibitor Anti-cancer&immunity PI3K/Akt/mTOR Akt mTOR PI3K Cell Cycle Regulation apis