Atractylenolide-1
- CAS No.
- 73069-13-3
- Chemical Name:
- Atractylenolide-1
- Synonyms
- Extracted oil;Dictyolactone I;Atracylenolide I;ATRACTYLENOLIDE-1;Atractylenolide Ⅰ;8,9-Dehydroasterolide;Atractylenolide I, >99%;Eudesma-4(15),7(11),8-trien-12-olide;Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one
- CBNumber:
- CB5847745
- Molecular Formula:
- C15H18O2
- Molecular Weight:
- 230.3
- MDL Number:
- MFCD09037395
- MOL File:
- 73069-13-3.mol
- MSDS File:
- SDS
Atractylenolide-1 price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A2737 | Atractylenolide I ≥98% (HPLC) | 73069-13-3 | 10mg | $371 | 2024-03-01 | Buy |
Sigma-Aldrich | A2737 | Atractylenolide I ≥98% (HPLC) | 73069-13-3 | 50mg | $1080 | 2023-06-20 | Buy |
Cayman Chemical | 25061 | Atractylenolide I ≥98% | 73069-13-3 | 5mg | $141 | 2024-03-01 | Buy |
Cayman Chemical | 25061 | Atractylenolide I ≥98% | 73069-13-3 | 10mg | $267 | 2024-03-01 | Buy |
Cayman Chemical | 25061 | Atractylenolide I ≥98% | 73069-13-3 | 25mg | $455 | 2024-03-01 | Buy |
Atractylenolide-1 Chemical Properties,Uses,Production
Description
Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.
Atractylenolide-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16223 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Atractylenolide-1 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-12 | Atractylenolide-1
73069-13-3
|
US $0.00-0.00 / kg | 1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2024-04-12 | Atractylenolide I
73069-13-3
|
US $0.00 / kg | 1kg | 98% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
2023-02-24 | Atractylenolide I
73069-13-3
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
- Atractylenolide-1
73069-13-3
- US $0.00-0.00 / kg
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
- Atractylenolide I
73069-13-3
- US $0.00 / kg
- 98%
- Shaanxi Haibo Biotechnology Co., Ltd
- Atractylenolide I
73069-13-3
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.