MAF
- CAS No.
- 101365-54-2
- Chemical Name:
- MAF
- Synonyms
- MAF;C-Maf;4hopcp;4-ho-pcp;MAF power;IFN-γ human;T cell interferon;Immune Interferon;type II interferon;Proto-oncogene c-maf
- CBNumber:
- CB5852420
- Molecular Formula:
- C22H29ClN2O2
- Molecular Weight:
- 388.94
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; Methanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A neat solid |
| Stability | Hygroscopic |
| FDA UNII | SFJ7C36NLQ |
MAF Chemical Properties,Uses,Production
Uses
IFN-γ (interferon γ)-human has been used for the generation of inflammatory M1 cells from human monocytic cell line, THP1.
General Description
IFN-γ (interferon γ) is an acid-labile glycosylated interferon produced by CD4 and CD8 T lymphocytes as well as activated NK (natural killer) cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC (major histocompatibility complex) proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. The gene is mapped to human chromosome 12q15. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7kDa protein containing 143 amino acid residues.
Biochem/physiol Actions
IFN-γ (interferon γ) signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. It can suppress the generation of anti-inflammatory cytokines and enhance the secretion of proinflammatory cytokines. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK (natural killer) cells and neutrophils. It is responsible for tumor rejection and is capable of killing tumor cells by autophagy or apoptosis. IFN-γ is also involved in Hepatitis E virus disease pathogenesis.
MAF Preparation Products And Raw materials
Raw materials
Preparation Products
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