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4-Chloro-3-methylphenol

4-Chloro-3-methylphenol
4-Chloro-3-methylphenol structure
CAS No.
59-50-7
Chemical Name:
4-Chloro-3-methylphenol
Synonyms
KCY;UCK;UMK;CMK;CMPK;PCMC;CMPK1;4-CMC;Aptal;Parol
CBNumber:
CB5703115
Molecular Formula:
C7H7ClO
Formula Weight:
142.58
MOL File:
59-50-7.mol

4-Chloro-3-methylphenol Properties

Melting point:
63-65 °C(lit.)
Boiling point:
235 °C(lit.)
Density 
1.370
vapor pressure 
<0.1 hPa (20 °C)
refractive index 
1.5449 (estimate)
Flash point:
118 °C
storage temp. 
-20°C
solubility 
methanol: soluble1g/10 mL, clear, colorless
pka
pKa 9.55(t = 25) (Uncertain)
form 
Tablets
color 
White
PH
6.5 (1g/l, H2O, 20℃)
Water Solubility 
4 g/L (20 ºC)
Merck 
14,2133
BRN 
1237629
Stability:
Stable. Incompatible with brass, oxidizing agents, copper, copper alloys.
InChIKey
CFKMVGJGLGKFKI-UHFFFAOYSA-N
CAS DataBase Reference
59-50-7(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 4-chloro-3-methyl-(59-50-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N,T,F
Risk Statements  21/22-41-43-50-39/23/24/25-23/24/25-11-38
Safety Statements  26-36/37/39-61-45-36/37-16-7-28
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  GO7100000
Autoignition Temperature 590 °C
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
HS Code  29081000
Hazardous Substances Data 59-50-7(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 1830 mg/kg LD50 dermal Rat > 2000 mg/kg
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P391 Collect spillage. Hazardous to the aquatic environment
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

4-Chloro-3-methylphenol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C55402 4-Chloro-3-methylphenol 99% 59-50-7 5g $17.4 2018-11-13 Buy
Sigma-Aldrich 24940 4-Chloro-3-methylphenol ≥98.0% (HPLC) 59-50-7 1kg-f $63.4 2018-11-13 Buy
TCI Chemical C0150 4-Chloro-m-cresol >99.0%(GC) 59-50-7 25g $35 2018-11-22 Buy
TCI Chemical C0150 4-Chloro-m-cresol >99.0%(GC) 59-50-7 500g $122 2018-11-22 Buy
Alfa Aesar A17823 4-Chloro-3-methylphenol, 99% 59-50-7 500g $44.7 2018-11-15 Buy

4-Chloro-3-methylphenol Chemical Properties,Uses,Production

Chemical Properties

white or pink crystals

Chemical Properties

White (pure) or pink crystalline solid. Crystals turn pink on exposure to air and light. Phenolic odor.

Chemical Properties

Colorless or almost colorless, dimorphous crystals or crystalline powder with a characteristic phenolic odor.

Uses

antiinfectant

Uses

Disinfectant; pharmaceutic aid (preservative).

Production Methods

Chlorocresol is prepared by the chlorination of m-cresol.

General Description

A pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.

Air & Water Reactions

Hygroscopic. Soluble in aqueous base.

Reactivity Profile

4-Chloro-3-methylphenolS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys .

Hazard

Irritant to skin.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Pharmaceutical Applications

Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane. Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media. Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.

Contact allergens

Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.

Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An allergen. Mutation data reported. Incompatible with sodium hydroxide. When heated to decomposition it emits toxic fumes of Cl and phosgene. See also CRESOL and CHLOROPHENOLS.

Safety

Chlorocresol is used primarily as a preservative in topical pharmaceutical formulations but has also been used in nebulized solutions and ophthalmic and parenteral preparations. It should not, however, be used in formulations for intrathecal, intracisternal, or peridural injection.
Chlorocresol is metabolized by conjugation with glucuronic acid and sulfate and is excreted in the urine, mainly as the conjugate, with little chlorocresol being excreted unchanged. Although less toxic than phenol, chlorocresol may be irritant to the skin, eyes, and mucous membranes, and has been reported to cause some adverse reactions when used as an excipient.
Sensitization reactions may follow the prolonged application of strong solutions to the skin, although patch tests have shown that chlorocresol is not a primary irritant at concentrations up to 0.2%. Chlorocresol is recognized as a rare cause of allergic contact dermatitis. Cross sensitization with the related preservative chloroxylenol has also been reported. At concentrations of 0.005% w/v, chlorocresol has been shown to produce a reversible reduction in the ciliary movement of human nasal epithelial cells in vitro, and at concentrations of 0.1% chlorocresol produces irreversible ciliostasis; therefore it should be used with caution in nasal preparations. However, a clinical study in asthma patients challenged with chlorocresol or saline concluded that preservative might be used safely in nebulizer solution.
Chlorocresol is approved as safe for use in cosmetics in Europe at a maximum concentration of 0.2%, although not in products intended to come in contact with mucous membranes.
Chlorocresol at a concentration as low as 0.05% produces ocular irritation in rabbits. Despite such reports, chlorocresol has been tested in ophthalmic preparations.
When used systemically, notably in a heparin injection preserved with chlorocresol 0.15%, delayed irritant and hypersensitivity reactions attributed to chlorocresol have been reported.
LD50 (mouse, IV): 0.07 g/kg
LD50 (mouse, oral): 0.6 g/kg
LD50 (mouse, SC): 0.36 g/kg
LD50 (rabbit, dermal): >5 g/kg
LD50 (rat, dermal): >2 g/kg
LD50 (rat, oral): 1.83 g/kg
LD50 (rat, SC): 0.4 g/kg

Potential Exposure

Chlorinated phenol fungicide, microbiocide, and germicide used to control bacteria, yeasts, and fungi.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions) if breathing has stopped, and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Do not induce vomiting when formulations containing petroleum solvents are ingested. Otherwise, give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

storage

Chlorocresol is stable at room temperature but is volatile in steam. Aqueous solutions may be sterilized by autoclaving. On exposure to air and light, aqueous solutions may become yellow colored. Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

Shipping

UN2669 Chlorocresols solution, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3437 Chlorocresols solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise the phenol from pet ether or *C6H6. [Beilstein 6 H 381, 6 I 187, 6 II 355, 6 III 1315, 6 IV 2064.]

Incompatibilities

Chlorocresols react with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Contact with oxidizing agents may cause a fire and explosion hazard. Heat produces phosgene, hydrogen chloride and chlorine gases. Corrosive to aluminum, copper, tin, and other chemically active metals.

Incompatibilities

Chlorocresol can decompose on contact with strong alkalis, evolving heat and fumes that ignite explosively. It is also incompatible with oxidizing agents, copper, and with solutions of calcium chloride, codeine phosphate, diamorphine hydrochloride, papaveretum, and quinine hydrochloride. Chlorocresol is corrosive to metals and forms complex compounds with transition metal ions; discoloration occurs with iron salts. Chlorocresol also exhibits strong sorption or binding tendencies to organic materials such as rubber, certain plastics, and nonionic surfactants.
Chlorocresol may be lost from solutions to rubber closures, and in contact with polyethylene may initially be rapidly removed by sorption and then by permeation, the uptake being temperature dependent. Presoaking of components may reduce losses due to sorption, but not those by permeation. Chlorocresol may also be taken up by polymethylmethacrylate and by cellulose acetate. Losses to polypropylene or rigid polyvinyl chloride are usually small.
At a concentration of 0.1%, chlorocresol may be completely inactivated in the presence of nonionic surfactants, such as polysorbate 80. However, other studies have suggested an enhancement of antimicrobial properties in the presence of surfactants. Bactericidal activity is also reduced, due to binding, by cetomacrogol, methylcellulose, pectin, or cellulose derivatives. In emulsified or solubilized systems, chlorocresol readily partitions into the oil phase, particularly into vegetable oils, and higher concentrations will be required for efficient preservation.

Waste Disposal

A good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical creams and emulsions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
In Europe, chlorocresol is approved for use in cosmetics at a maximum concentration of 0.2%; however, it is prohibited for use in products intended to come into contact with mucous membranes. In Japan, use of chlorocresol in cosmetics is restricted to a level of 0.5 g/100 g.

4-Chloro-3-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products


4-Chloro-3-methylphenol Suppliers

Global( 241)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Aoxuan Biological Technology Co., Ltd.
17073140108
- CHINA 147 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1669 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 306 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4557 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 901 58

View Lastest Price from 4-Chloro-3-methylphenol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-25 4-Chloro-3-methylphenol
59-50-7
US $100.00 / KG 1KG 98% 10tons,20tons career henan chemical co
2019-03-26 High purity 4-Chloro-3-methylphenol
59-50-7
US $1.00 / kg 1 kg/桶 99% 20tons Hebei Jimi Trading Co., Ltd.
2017-10-18 4-CEC;4cec
59-50-7
US $100.00 / G 1G 99.5% skype/email:lila@tuskwei.com whatsapp:+8617197824208 500kgs per week Hebei Jiangkai Trading Co., Ltd

4-Chloro-3-methylphenol Spectrum


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