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4-Chloro-3-methylphenol

4-Chloro-3-methylphenol
4-Chloro-3-methylphenol structure
CAS No.
59-50-7
Chemical Name:
4-Chloro-3-methylphenol
Synonyms
KCY;UCK;UMK;CMK;CMPK;PCMC;CMPK1;Aptal;Parol;4-CMC
CBNumber:
CB5703115
Molecular Formula:
C7H7ClO
Formula Weight:
142.58
MOL File:
59-50-7.mol

4-Chloro-3-methylphenol Properties

Melting point:
63-65 °C(lit.)
Boiling point:
235 °C(lit.)
Density 
1.370
vapor pressure 
<0.1 hPa (20 °C)
refractive index 
1.5449 (estimate)
Flash point:
118 °C
storage temp. 
-20°C
solubility 
methanol: soluble1g/10 mL, clear, colorless
pka
pKa 9.55(t = 25) (Uncertain)
form 
Tablets
color 
White
PH
6.5 (1g/l, H2O, 20℃)
Water Solubility 
4 g/L (20 ºC)
Merck 
14,2133
BRN 
1237629
Henry's Law Constant
2.5(x 10-6 atm?m3/mol)at 20 °C (calculated, Mabey et al., 1982)
Stability:
Stable. Incompatible with brass, oxidizing agents, copper, copper alloys.
InChIKey
CFKMVGJGLGKFKI-UHFFFAOYSA-N
Indirect Additives used in Food Contact Substances
4-CHLORO-3-METHYLPHENOL
CAS DataBase Reference
59-50-7(CAS DataBase Reference)
FDA 21 CFR
175.105; 176.200
EWG's Food Scores
5
FDA UNII
36W53O7109
NIST Chemistry Reference
Phenol, 4-chloro-3-methyl-(59-50-7)
EPA Substance Registry System
p-Chloro-m-cresol (59-50-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS05,GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H335-H373-H302-H312-H225-H301+H311+H331-H370-H302+H312-H317-H318-H400-H410
Precautionary statements  P264-P270-P271-P272-P302+P352+P312+P362+P364-P304+P340+P312-P314-P391-P403+P233-P405-P501-P261-P301+P312a-P310a-P501a-P210-P260-P280-P301+P310-P311-P273-P305+P351+P338-P301+P312+P330-P305+P351+P338+P310
Hazard Codes  Xn,N,T,F
Risk Statements  21/22-41-43-50-39/23/24/25-23/24/25-11-38
Safety Statements  26-36/37/39-61-45-36/37-16-7-28
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  GO7100000
Autoignition Temperature 590 °C
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
HS Code  29081000
Toxicity LD50 orally in Rabbit: 1830 mg/kg LD50 dermal Rat > 2000 mg/kg

4-Chloro-3-methylphenol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C55402 4-Chloro-3-methylphenol 99% 59-50-7 5g $17.7 2019-12-02 Buy
Sigma-Aldrich 24940 4-Chloro-3-methylphenol ≥98.0% (HPLC) 59-50-7 1kg-f $64.2 2019-12-02 Buy
TCI Chemical C0150 4-Chloro-m-cresol >99.0%(GC) 59-50-7 25g $40 2020-06-24 Buy
TCI Chemical C0150 4-Chloro-m-cresol >99.0%(GC) 59-50-7 500g $138 2020-06-24 Buy
Alfa Aesar A17823 4-Chloro-3-methylphenol, 99% 59-50-7 500g $47.5 2020-06-24 Buy

4-Chloro-3-methylphenol Chemical Properties,Uses,Production

Chemical Properties

white or pink crystals

Chemical Properties

White (pure) or pink crystalline solid. Crystals turn pink on exposure to air and light. Phenolic odor.

Chemical Properties

Colorless or almost colorless, dimorphous crystals or crystalline powder with a characteristic phenolic odor.

Physical properties

Colorless, white, or pinkish crystals with a slight phenolic odor. On exposure to air it slowly becomes light brown.

Uses

P-chloro-m-cresol is used as a preservative in a wide number of topical preparations and is a rare cause of allergic contact dermatitis and CoU, the mechanism of which remains uncertain.

Uses

antiinfectant

Uses

Disinfectant; pharmaceutic aid (preservative).

Production Methods

Chlorocresol is prepared by the chlorination of m-cresol.

General Description

A pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.

Air & Water Reactions

Hygroscopic. Soluble in aqueous base.

Reactivity Profile

4-Chloro-3-methylphenolS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys .

Hazard

Irritant to skin.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Pharmaceutical Applications

Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane. Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media. Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.

Contact allergens

Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.

Side effects

Chlorocresol is used as a preservative in a variety of topical preparations, such as corticosteroid creams and moisturizers and in disinfectants and detergents. Three case reports implicate chlorocresol as a cause of Cou; however, whether this is due to an immunological cause is uncertain.
Walker et al. report a patient who experienced localized Cou to a number of topical medicaments and moisturizers within 30 minutes of application. Patch tests of chlorocresol and her own preparations containing chlorocresol applied for just 30 minutes produced marked urticarial responses.
A woman working in an aviary developed eyelid edema and erythema every time she used two specific disinfectants. Open and skin prick testing to 10%, but not 1%, chlorocresol was positive in this case and negative in 10 controls. This patient also experienced eyelid involvement as well as local reactions to the testing, both with superficial necrosis. Freitas et al. acknowledged that it was unusual on both aspects: for such a high concentration to be required to elicit an urticarial reaction and for superficial necrosis to occur.
A case of simultaneous delayed and immediate hypersensitivity has also been reported. Goncalo et al. report a 35-year-old laboratory worker exposed to chlorocresol in both detergents and corticosteroid creams. Patch testing was positive and the patient was diagnosed with allergic contact dermatitis to chlorocresol, which was present in numerous products. Open and skin prick testing to 1% and 5% chlorocresol were positive after 20 minutes. Ten controls were also tested, all were negative to the 1% formulation, although six were positive to 5%,[48] suspicious for a nonimmunological Cou.

Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An allergen. Mutation data reported. Incompatible with sodium hydroxide. When heated to decomposition it emits toxic fumes of Cl and phosgene. See also CRESOL and CHLOROPHENOLS.

Safety

Chlorocresol is used primarily as a preservative in topical pharmaceutical formulations but has also been used in nebulized solutions and ophthalmic and parenteral preparations. It should not, however, be used in formulations for intrathecal, intracisternal, or peridural injection.
Chlorocresol is metabolized by conjugation with glucuronic acid and sulfate and is excreted in the urine, mainly as the conjugate, with little chlorocresol being excreted unchanged. Although less toxic than phenol, chlorocresol may be irritant to the skin, eyes, and mucous membranes, and has been reported to cause some adverse reactions when used as an excipient.
Sensitization reactions may follow the prolonged application of strong solutions to the skin, although patch tests have shown that chlorocresol is not a primary irritant at concentrations up to 0.2%. Chlorocresol is recognized as a rare cause of allergic contact dermatitis. Cross sensitization with the related preservative chloroxylenol has also been reported. At concentrations of 0.005% w/v, chlorocresol has been shown to produce a reversible reduction in the ciliary movement of human nasal epithelial cells in vitro, and at concentrations of 0.1% chlorocresol produces irreversible ciliostasis; therefore it should be used with caution in nasal preparations. However, a clinical study in asthma patients challenged with chlorocresol or saline concluded that preservative might be used safely in nebulizer solution.
Chlorocresol is approved as safe for use in cosmetics in Europe at a maximum concentration of 0.2%, although not in products intended to come in contact with mucous membranes.
Chlorocresol at a concentration as low as 0.05% produces ocular irritation in rabbits. Despite such reports, chlorocresol has been tested in ophthalmic preparations.
When used systemically, notably in a heparin injection preserved with chlorocresol 0.15%, delayed irritant and hypersensitivity reactions attributed to chlorocresol have been reported.
LD50 (mouse, IV): 0.07 g/kg
LD50 (mouse, oral): 0.6 g/kg
LD50 (mouse, SC): 0.36 g/kg
LD50 (rabbit, dermal): >5 g/kg
LD50 (rat, dermal): >2 g/kg
LD50 (rat, oral): 1.83 g/kg
LD50 (rat, SC): 0.4 g/kg

Potential Exposure

Chlorinated phenol fungicide, microbiocide, and germicide used to control bacteria, yeasts, and fungi.

Environmental Fate

Biological. When p-chloro-m-cresol was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, significant biodegradation with rapid adaptation was observed. At concentrations of 5 and 10 mg/L, 78 and 76% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981).
Chemical/Physical. At influent concentrations (pH 3.0) of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 122, 63, 32, and 17 mg/g, respectively. At pH 5.5 and pH 9.0 at influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 124, 85, 58, and 40 mg/g and 99, 38, 15, and 5.5 mg/g, respectively (Dobbs and Cohen, 1980).

storage

Chlorocresol is stable at room temperature but is volatile in steam. Aqueous solutions may be sterilized by autoclaving. On exposure to air and light, aqueous solutions may become yellow colored. Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

Shipping

UN2669 Chlorocresols solution, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3437 Chlorocresols solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise the phenol from pet ether or *C6H6. [Beilstein 6 H 381, 6 I 187, 6 II 355, 6 III 1315, 6 IV 2064.]

Incompatibilities

Chlorocresols react with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Contact with oxidizing agents may cause a fire and explosion hazard. Heat produces phosgene, hydrogen chloride and chlorine gases. Corrosive to aluminum, copper, tin, and other chemically active metals.

Incompatibilities

Chlorocresol can decompose on contact with strong alkalis, evolving heat and fumes that ignite explosively. It is also incompatible with oxidizing agents, copper, and with solutions of calcium chloride, codeine phosphate, diamorphine hydrochloride, papaveretum, and quinine hydrochloride. Chlorocresol is corrosive to metals and forms complex compounds with transition metal ions; discoloration occurs with iron salts. Chlorocresol also exhibits strong sorption or binding tendencies to organic materials such as rubber, certain plastics, and nonionic surfactants.
Chlorocresol may be lost from solutions to rubber closures, and in contact with polyethylene may initially be rapidly removed by sorption and then by permeation, the uptake being temperature dependent. Presoaking of components may reduce losses due to sorption, but not those by permeation. Chlorocresol may also be taken up by polymethylmethacrylate and by cellulose acetate. Losses to polypropylene or rigid polyvinyl chloride are usually small.
At a concentration of 0.1%, chlorocresol may be completely inactivated in the presence of nonionic surfactants, such as polysorbate 80. However, other studies have suggested an enhancement of antimicrobial properties in the presence of surfactants. Bactericidal activity is also reduced, due to binding, by cetomacrogol, methylcellulose, pectin, or cellulose derivatives. In emulsified or solubilized systems, chlorocresol readily partitions into the oil phase, particularly into vegetable oils, and higher concentrations will be required for efficient preservation.

Waste Disposal

A good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical creams and emulsions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
In Europe, chlorocresol is approved for use in cosmetics at a maximum concentration of 0.2%; however, it is prohibited for use in products intended to come into contact with mucous membranes. In Japan, use of chlorocresol in cosmetics is restricted to a level of 0.5 g/100 g.

4-Chloro-3-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products


4-Chloro-3-methylphenol Suppliers

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View Lastest Price from 4-Chloro-3-methylphenol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-29 4-Chloro-3-methylphenol
59-50-7
US $0.00 / Kg/Drum 200KG 99% 200 tons/year YANGZHOU SHUANGDING CHEM CO., LTD
2019-07-03 4-Chloro-3-methylphenol
59-50-7
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-05-09 4-Chloro-3-methylphenol
59-50-7
US $0.00 / Kg/Drum 1KG 99% 20tons hdzhl biotechnology co., ltd

4-Chloro-3-methylphenol Spectrum


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