Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
![Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) Structure](CAS/GIF/126069-70-3.gif)
- CAS No.
- 126069-70-3
- Chemical Name:
- Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
- Synonyms
- 8-METHYL-2-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRAZINE;2-(trifluoroMethyl)-5H,6H,7H,8H-iMidazo[1,2-a]pyrazine;2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE;5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine;IMidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoroMethyl)-;2-(TrifluoroMethyl)-5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine HCl;2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2HCl;Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI);2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
- CBNumber:
- CB61043282
- Molecular Formula:
- C7H8F3N3
- Molecular Weight:
- 191.15
- MDL Number:
- MFCD09834983
- MOL File:
- 126069-70-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H318 |
| Precautionary statements | P280-P301+P310+P330-P305+P351+P338+P310 |
| Hazard Codes | Xi |
| Risk Statements | 41 |
| Safety Statements | 26-39 |
| RIDADR | UN 2811 6.1 / PGIII |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000185 | 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine | 126069-70-3 | 1g | $201 | 2023-01-07 | Buy |
| TRC | T797168 | 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine | 126069-70-3 | 1g | $310 | 2021-12-16 | Buy |
| Apolloscientific | PC520909 | 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 95% | 126069-70-3 | 5g | $434 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H31-3-7E | 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 95% | 126069-70-3 | 5G | $695 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0049752 | 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE 95.00% | 126069-70-3 | 500MG | $756.53 | 2021-12-16 | Buy |
Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) Chemical Properties,Uses,Production
Uses
2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine is used to study fused heterocycle-linked triazole derivatives.
Synthesis
![2-(TRIFLUOROMETHYL)IMIDAZOL[1,2-A]PYRAZINE](/CAS/GIF/109113-96-4.gif)
109113-96-4
![Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)](/CAS/GIF/126069-70-3.gif)
126069-70-3
The general procedure for the synthesis of 2-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine using 2-trifluoromethylimidazo[1,2-a]pyrazine as a starting material was as follows: 2-trifluoromethylimidazo[1,2-a]pyrazine (2.40 g, 12.55 mmol) was dissolved in methanol (100 mL) with 10% Pd/C catalyst (480 mg ). The reaction system was displaced three times with hydrogen to ensure an oxygen-free environment. After stirring the reaction for 12 h at room temperature, the catalyst was removed by filtration and the filter cake was washed with methanol. The filtrates were combined and concentrated under reduced pressure to afford 2-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (2.30 g, 95.8% yield) as a yellow oil.
References
[1] Patent: EP2604610, 2013, A1. Location in patent: Paragraph 0114; 0116
[2] Patent: US2013/131068, 2013, A1. Location in patent: Paragraph 0165
[3] Patent: WO2010/125101, 2010, A1. Location in patent: Page/Page column 51-52
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[5] Patent: WO2006/9886, 2006, A1. Location in patent: Page/Page column 43
Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | sales@scochem.com | China | 1977 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3767 | 58 |
View Lastest Price from Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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![Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) pictures](https://img.chemicalbook.com/ProductImageEN/2019-7/Small/37d54b7e-61f9-48a2-a0b5-b8689ae91a6a.jpg) |
2019-07-10 | Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
126069-70-3
|
US $1.00 / KG | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
126069-70-3
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
