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3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1)

3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) structure

CAS No.: 1454658-89-9

Chemical Name:: 3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1)

Synonyms: MW108;MW-108;MW 108;MW0111108;MW01-11-108;MW01 11 108;3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1)

CBNumber:: CB610779914

Molecular Formula:: C21H19ClN4

Molecular Weight:: 362.86

MDL Number:

MOL File:: 1454658-89-9.mol

Last updated:2025-08-21 16:37:02

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3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Chemical Properties,Uses,Production

Description

MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor. It acts by ameliorating beta-amyloid induced synaptic and cognitive dysfunction and preventing early memory loss in Alzheimer's disease.

Uses

MW108 (MW01-11-108SRM) hydrochloride is a selective and CNS-penetrant p38αMAPK inhibitor with a Ki of 114 nM. MW108 hydrochloride ameliorates beta-amyloid induced synaptic and cognitive dysfunction[1].

IC 50

p38α MAPK: 114 nM (Ki)

References

[1] D Martin Watterson, et al. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PLoS One. 2013 Jun 26;8(6):e66226. DOI:10.1371/journal.pone.0066226

3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Preparation Products And Raw materials

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3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) Suppliers

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Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19962	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29641	58

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TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Lastest Price from 3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-08-21	MW108 1454658-89-9	US $1980.00-1520.00 / mg			10g	TargetMol Chemicals Inc.

MW108
1454658-89-9
US $1980.00-1520.00 / mg
TargetMol Chemicals Inc.

3-Pyridazinamine, N,N-dimethyl-6-(2-naphthalenyl)-5-(4-pyridinyl)-, hydrochloride (1:1) MW 108 MW01 11 108 MW0111108 MW01-11-108 MW108 MW-108 1454658-89-9