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Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- structure

CAS No.: 1318793-78-0

Chemical Name:: Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-

Synonyms: YSK05;Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-

CBNumber:: CB611360694

Molecular Formula:: C42H77NO2

Molecular Weight:: 628.07

MDL Number:

MOL File:: 1318793-78-0.mol

Last updated:2023-07-12 16:53:27

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Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Properties

Boiling point	663.6±55.0 °C(Predicted)
Density	0.91±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Ethanol: 25 mg/ml
pka	7.51±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319

Precautionary statements

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501

NFPA 704

	3
2		0

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Chemical Properties,Uses,Production

Biological Activity

YSK05 is an ionizable amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).1,2,3 Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.2 Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.3

References

1.Sato, Y., Hatakeyama, H., Sakurai, Y., et al.A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivoJ. Control. Release163(3)267-276(2012) 2.Nakamura, T., Miyabe, H., Hyodo, M., et al.Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanomaJ. Control. Release216149-157(2015) 3.Sato, Y., Note, Y., Maeki, M., et al.Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA deliveryJ. Control. Release22948-57(2016)

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shochem(Shanghai)Co.,Ltd	+86-021-51783479 +86-13816874662	info@shochem.com	China	311	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	2981	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Shochem (Shanghai) Co.,Ltd	13611745246 13816874662	sales@shochem.com	China	431	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	36683	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9180	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58

Supplier	Advantage
Shochem(Shanghai)Co.,Ltd	58
DC Chemicals	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Shochem (Shanghai) Co.,Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58

1318793-78-0(Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-)Related Search:

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Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- YSK05 1318793-78-0