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YS121

YS121 Structure
YS121 structure
CAS No.
916482-17-2
Chemical Name:
YS121
Synonyms
YS121;YS121 Exclusive;HVJBWTVMRIOTEL-UHFFFAOYSA-N;Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
CBNumber:
CB92592892
Molecular Formula:
C20H26ClN3O2S
Molecular Weight:
407.96
MDL Number:
MFCD18382121
MOL File:
916482-17-2.mol
Last updated:2023-06-08 09:02:11
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YS121 Properties

Boiling point 557.4±50.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka 3.04±0.21(Predicted)
form solution in acetate.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
NFPA 704
3
2 0

YS121 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13665 YS-121 ≥98% 916482-17-2 1mg $55 2024-03-01 Buy
Cayman Chemical 13665 YS-121 ≥98% 916482-17-2 5mg $236 2024-03-01 Buy
Cayman Chemical 13665 YS-121 ≥98% 916482-17-2 10mg $420 2024-03-01 Buy
Cayman Chemical 13665 YS-121 ≥98% 916482-17-2 25mg $914 2024-03-01 Buy
AK Scientific 1614DC 2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid 916482-17-2 10mg $564 2021-12-16 Buy
Product number Packaging Price Buy
13665 1mg $55 Buy
13665 5mg $236 Buy
13665 10mg $420 Buy
13665 25mg $914 Buy
1614DC 10mg $564 Buy

YS121 Chemical Properties,Uses,Production

Description

Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.

Definition

ChEBI: Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]- is a medium-chain fatty acid.

References

[1] koeberle a, zettl h, greiner c, et al. pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of medicinal chemistry, 2008, 51(24): 8068-8076.
[2] mehrotra s, morimiya a, agarwal b, et al. microsomal prostaglandin e2 synthase‐1 in breast cancer: a potential target for therapy[j]. the journal of pathology, 2006, 208(3): 356-363.werz o, greiner c, koeberle a, et al. novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid[j]. journal of medicinal chemistry, 2008, 51(17): 5449-5453.koeberle a, rossi a, zettl h, et al. the molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2, 3-dimethylphenylamino) pyrimidin-2-ylthio) octanoic acid (ys121), a dual inhibitor of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of pharmacology and experimental therapeutics, 2010, 332(3): 840-848.

YS121 Preparation Products And Raw materials

Raw materials

Preparation Products

YS121 Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3421 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29989 58
RD International Technology Co., Limited 18988968278 sales@ubiochem.com China 9146 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58
RD International Technology Co., Limited 58
ApexBio Technology 58

916482-17-2(YS121)Related Search:

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YS121 HVJBWTVMRIOTEL-UHFFFAOYSA-N YS121 Exclusive Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]- 916482-17-2