Adenylyl Imidodiphosphate
- CAS No.
- 25612-73-1
- Chemical Name:
- Adenylyl Imidodiphosphate
- Synonyms
- AMP-PNP;AMP-P(NH)P;β,γ-ImidoATP;β,γ-Imido-ATP;93% (HPLC), powder;Adenyl imidodiphosphate;Adenylyl Imidodiphosphate;Adenylyl beta,gamma-imidodiphosphate;Adenosine 5′-(β,γ-imido)triphosphate;Adenosine beta,gamma-imidotriphosphate
- CBNumber:
- CB61321108
- Molecular Formula:
- C10H17N6O12P3
- Molecular Weight:
- 506.2
- MDL Number:
- MOL File:
- 25612-73-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
Adenylyl Imidodiphosphate price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2647 | Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate ≥93% (HPLC), powder | 25612-73-1 | 5mg | $105 | 2024-03-01 | Buy |
| Sigma-Aldrich | A2647 | Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate ≥93% (HPLC), powder | 25612-73-1 | 25mg | $361 | 2024-03-01 | Buy |
| Sigma-Aldrich | 10102547001 | AMP-PNP Adenylyl-imidodiphosphate | 25612-73-1 | 25mg | $243 | 2024-03-01 | Buy |
| Sigma-Aldrich | A2647 | Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate ≥93% (HPLC), powder | 25612-73-1 | 100mg | $1220 | 2024-03-01 | Buy |
| Tocris | 6086 | AMPPNP ≥90%(HPLC) | 25612-73-1 | 10 | $162 | 2021-12-16 | Buy |
Adenylyl Imidodiphosphate Chemical Properties,Uses,Production
Uses
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.
Uses
AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase.
AMP-PNP has been used for two-motor fluorescence assay.
Definition
ChEBI: AMP-PNP is an adenosine 5'-phosphate.
General Description
AMP-PNP(adenylyl-imidodiphosphate) is an artificial substrate of enzyme, adenylate cyclase. Adenylate cyclase helps to hydrolyze adenylyl-imidodiphosphate slowly than ATP.
Biochem/physiol Actions
A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.
Adenylyl Imidodiphosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Adenylyl Imidodiphosphate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 16168 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| JiangSu Star Science Co.,Ltd | 400-605-7200 17312445705 | sales022@b2star.com | China | 3764 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 39990 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb5@aikonchem.com | China | 10529 | 58 |
| Henan Fangding Technology Co., LTD | 15670369782 | 15670369782@163.com | China | 9828 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |