ChemicalBook >> CAS DataBase List >>H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH structure

CAS No.: 249537-73-3

Chemical Name:: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

Synonyms: VIVIT;NFAT INHIBITOR;MAGPHPVIVITGPHEE;NFAT Inhibitor-1;NFAT INHIBITOR?, >98%;NFAT Inhibitor (VIVIT peptide);NFAT Inhibitor >96% (HPLC), solid;NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%;MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU;H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

CBNumber:: CB6148948

Molecular Formula:: C75H118N20O22S

Molecular Weight:: 1683.93

MDL Number:: MFCD02683959

MOL File:: 249537-73-3.mol

MSDS File:: SDS

Last updated:2024-03-27 11:49:37

Request For Quotation

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Properties

Boiling point	1982.4±65.0 °C(Predicted)
Density	1.334±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 15 mg/ml; Water: 10 mg/ml
form	solid
pka	3.12±0.10(Predicted)
Water Solubility	Soluble to 2 mg/ml in water
Sequence	H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements	22-24/25
WGK Germany	3
HS Code	2933299090

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N7032	NFAT Inhibitor >96% (HPLC), solid	249537-73-3	1MG	$595	2024-03-01	Buy
Sigma-Aldrich	480402	NFAT Inhibitor The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.		500μG	$166	2024-03-01	Buy
Cayman Chemical	13855	NFAT Inhibitor ≥95%	249537-73-3	1mg	$82	2024-03-01	Buy
Cayman Chemical	13855	NFAT Inhibitor ≥95%	249537-73-3	5mg	$362	2024-03-01	Buy
Cayman Chemical	13855	NFAT Inhibitor ≥95%	249537-73-3	10mg	$642	2024-03-01	Buy

Product number	Packaging	Price	Buy
N7032	1MG	$595	Buy
480402	500μG	$166	Buy
13855	1mg	$82	Buy
13855	5mg	$362	Buy
13855	10mg	$642	Buy

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Chemical Properties,Uses,Production

Description

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).

Uses

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

storage

Store at -20°C

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
Hebei Miaoyin Technology Co.,Ltd	58
Nanjing TGpeptide	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64

View Lastest Price from H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-17	H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH 249537-73-3	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
249537-73-3
US $7.00 / KG
99%
Career Henan Chemical Co

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Spectrum

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH(249537-73-3)MS

249537-73-3(H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH)Related Search:

H-GLU-GLU-OH H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Nfat Inhibitor

MAGPHPVIVITGPHEE MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH NFAT INHIBITOR VIVIT NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98% NFAT INHIBITOR?, >98% NFAT Inhibitor (VIVIT peptide) L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl- NFAT Inhibitor >96% (HPLC), solid L-Methionyl-L-Alanylglycyl-L-Prolyl-L-Histidyl-L-Prolyl-L-Valyl-L-Isoleucyl-L-Valyl-L-Isoleucyl-L-Threonylglycyl-L-Prolyl-L-Histidyl-L-alpha-Glutamyl-L-Glutamic Acid NFAT Inhibitor-1 249537-73-3 C75H118N20O22S BioChemical Cell Signaling and Neuroscience Cell Biology Gene Regulation and Expression Gene Regulation Gene Regulation Cell Signaling and Neuroscience Gene Regulation and Expression