BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
![BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Structure](CAS/GIF/66778-36-7.gif)
- CAS No.
- 66778-36-7
- Chemical Name:
- BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
- Synonyms
- Enkaid;Enkade;MJ-9067;M-9067-1;Encainida;Encainidum;Brn 0497572;MJ-9067[AS BASE];Encainide [french];Encainida [spanish]
- CBNumber:
- CB6187332
- Molecular Formula:
- C22H28N2O2
- Molecular Weight:
- 352.47
- MDL Number:
- MFCD00864726
- MOL File:
- 66778-36-7.mol
| Product description | Number | Pack Size | Price |
| ENCAINIDE 95.00% | API0002544 | 100MG | $885.31 |
| ENCAINIDE 95.00% | API0002544 | 1G | $2355.15 |
| 4-Methoxy-N-(2-(2-(1-methylpiperidin-2-yl)ethyl)phenyl)benzamide 95+% | CD11075830 | 1g | $1488 |
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | White to off-white |
| FDA UNII | SY3J0147NB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0002544 | ENCAINIDE 95.00% | 66778-36-7 | 100MG | $885.31 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002544 | ENCAINIDE 95.00% | 66778-36-7 | 1G | $2355.15 | 2021-12-16 | Buy |
| Crysdot | CD11075830 | 4-Methoxy-N-(2-(2-(1-methylpiperidin-2-yl)ethyl)phenyl)benzamide 95+% | 66778-36-7 | 1g | $1488 | 2021-12-16 | Buy |
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Chemical Properties,Uses,Production
Chemical Properties
Light yellow crystal. Soluble in ether, insoluble in saturated saline. Encainide Hydroehloride: C22H28N2O2?HCI.[66794-74-9]. White crystal, melting point 131.5-132.5℃. Soluble in water, slightly soluble in alcohol, insoluble in ether or pentane. Acute toxicity LD50 mice, dogs (mg/kg): 86, 43 oral; 16, 17 intravenous.
Uses
Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research[1][2].
Definition
ChEBI: 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life- hreatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.
in vivo
Encainide (0.3, 0.9, 2.7 mg/kg; infusion of single doses) prolongs His-Purkinje conduction time (HV interval) and intra-ventricular conduction time (QRS duration) but has no effect on sinus nodal recovery time or AV nodal conduction, or on refractoriness of atrium, AV node, or ventricular myocardium or on QT interval[1].
References
[1] R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38. DOI:10.2165/00003495-198734050-00002
[2] Hongliang Li, et al. Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells. Korean J Physiol Pharmacol. 2023 Jul 1;27(4):399-406. DOI:10.4196/kjpp.2023.27.4.399
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12335 | 58 |
| Shanghai Merlot Chemical Co., LTD | 15821661757 | 226174156@qq.com | China | 476 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29257 | 58 |
| Shaanxi Xihua Chemical Industry Co., Ltd | 029-81136151 17392212881 | 1095@dideu.com | China | 9988 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 18013972705 | qqyang@aikonchem.com | China | 10151 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
