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2-Picoline structure
Chemical Name:
ALPHAP;NSC-3409;ai3-2409;aPicolin;2-PICOLINE;a-Picoline;o-Picoline;α-picoline;2-PICOLINE 98%;2-Picoline (2-
Molecular Formula:
Formula Weight:
MOL File:

2-Picoline Properties

Melting point:
-70 °C (lit.)
Boiling point:
128-129 °C (lit.)
0.942-0.946 at 20 °C 0.943 g/mL at 25 °C (lit.)
vapor density 
3.2 (vs air)
vapor pressure 
10 mm Hg ( 24.4 °C)
refractive index 
n20/D 1.500(lit.)
Flash point:
79 °F
storage temp. 
Store below +30°C.
H2O: freely soluble
5.97(at 20℃)
Clear pale yellow
8.5 (100g/l, H2O, 20℃)
explosive limit
Water Solubility 
Stable. Flammable. Incompatible with strong oxidizing agents, sulfuric acid, acids, metals, iron (II) sulfate, hydrogen peroxide. Hygroscopic.
CAS DataBase Reference
109-06-8(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Pyridine, 2-methyl-(109-06-8)
EPA Substance Registry System
2-Methylpyridine (109-06-8)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H302-H312-H332-H226-H302+H332-H311-H319-H335
Precautionary statements  P261-P280-P305+P351+P338-P312-P210-P303+P361+P353-P405-P501a
Hazard Codes  Xn,T
Risk Statements  10-20/21/22-36/37-24-20/22
Safety Statements  26-36-45-36/37
RIDADR  UN 2313 3/PG 3
WGK Germany  1
RTECS  TJ4900000
Autoignition Temperature 995 °F
HazardClass  3
PackingGroup  III
HS Code  29333999
Toxicity LD50 orally in rats: 1.41 g/kg (Smyth)
NFPA 704
3 0

2-Picoline price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 109835 2-Methylpyridine 98% 109-06-8 25ml $26.1 2021-03-22 Buy
Sigma-Aldrich 8.09722 2-Methylpyridine for synthesis 109-06-8 100 mL $29.97 2021-03-22 Buy
Sigma-Aldrich 8.09722 2-Methylpyridine for synthesis 109-06-8 500 mL $37.28 2021-03-22 Buy
Sigma-Aldrich 8.09722 2-Methylpyridine for synthesis 109-06-8 1 L $63.36 2021-03-22 Buy
Sigma-Aldrich 109835 2-Methylpyridine 98% 109-06-8 1l $58.5 2021-03-22 Buy

2-Picoline Chemical Properties,Uses,Production

Chemical Properties

colourless to yellow liquid with an unpleasant smell

Chemical Properties

Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.

Chemical Properties

2-Methylpyridine is highly stable in aqueous solutions but decomposes when heated to emit NOx. The chemical also may react with oxidizing agents.


2-Methylpyridine is released in atmospheric emissions from coal during processing into tar, pitch and coke (Windholz et al 1983; Naizer and Mashek 1974). It is also a byproduct of coal gasification and liquefaction processes (Pellizzori et al 1979; Stuermer et al 1982) and oil shale retorting (Pellizzari et al 1979). It is present in coal and is released in stack emissions (Opresko 1982). 2-Methylpyridine has been identified in effluences from the following industries: timber products, organic chemicals, pharmaceuticals and public waste treatment facilities (Schackleford and Cline 1983). 2-Methylpyridine also is a constituent of tobacco smoke (Brunneman 1978).
2-Methylpyridine is biodegradable. A 1 mM solution of 2-methylpyridine exposed in soil microorganism was completely degraded in 14-33 d under aerobic conditions, but not degraded after 97 d in anaerobic conditions (Naik et al 1972).


Solvent; intermediate in the dye and resins industries.

Production Methods

2-Methylpyridine is synthesized by distillation of coal tar or bone oil or by vapor phase reaction of acetaldehyde and ammonia in a 3:1 ratio followed by isolation of 2-methylpyridine from the reaction mixture (Considine 1974). It also can be synthesized from cyclohexylamine with excess ammonia and ZnCl2 at 350°C, resulting in a 40-50% yield; or prepared from ethylene-mercuric acetate adduct with ammonia water with a 70% yield (Windholz et al 1983). Production in 1977 probably exceeded one million pounds (Opresko 1982).

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 5355, 1964 DOI: 10.1021/ja01077a077
Synthesis, p. 26, 1976
Tetrahedron Letters, 17, p. 383, 1976 DOI: 10.1016/S0040-4039(00)93738-9

General Description

Colorless liquid with a strong, unpleasant odor. Floats on water. Poisonous vapor is produced.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

2-Picoline is hygroscopic. 2-Picoline reacts with hydrogen peroxide, iron(II) sulfate, sulfuric acid, oxidizing agents, acids, and metals.

Health Hazard

INHALATION, INGESTION OR SKIN ABSORPTION: Narcosis, headache, nausea, giddiness, vomiting. EYES: Severe irritation. SKIN: Causes burns. INGESTION: Irritation and gastric upset.

Health Hazard

2-Methylpyridine causes local irritation on contact with the skin, mucous membranes and cornea (Reinhardt and Brittelli 1981). Clinical signs of intoxication caused by the methyl pyridines include weight loss, diarrhea, weakness, ataxia and unconsciousness (Reinhardt and Brittelli 1981) as well as narcosis headache, nausea, giddiness and vomiting (Ketchen and Porter 1979). Chronic exposure to methylpyridine results in anemia and ocular and facial paralysis in addition to the previously mentioned symptoms (Ketchen and Porter 1979).

Industrial uses

2-Methylpyridine is used as a solvent, or as a chemical intermediate in the dye and resin industries (Windholz et al 1983) or for pharmaceuticals and rubber (Hawley 1981). It is used to make 2-vinylpyridine which is in turn made into a terpolymer with styrene and butadiene. The latexes of these terpolymers are extensively employed in adhesives for bonding textiles to elastomers (Reinhart and Britelli 1981). It is also a chemical intermediate for 2-chloro-6-(trichloromethyl)pyridine and 2-vinylpyridine.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. Mildly toxic by inhalation. A skin and severe eye irritant. Mutation data reported. Flammable liquid when exposed to heat or flame. To fight fire, use CO2, dry chemical. Mixtures with hydrogen peroxide + iron(II) sulfate + sulfuric acid may igmte and then explode. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

(o-isomer); Suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (m-isomer): Possible risk of forming tumors, Primary irritant (w/o allergic reaction). Picolines are used as intermediates in pharmaceutical manufacture, pesticide manufacture; and in the manufacture of dyes and rubber chemicals. It is also used as a solvent.


No reliable studies in mammals to evaluate the carcinogenic potential of any of the three methylpyridines were found. None of the methylpyridines is listed as a carcinogen by IARC, NTP, OSHA, or ACGIH.


Methylpyridines are absorbed by inhalation, ingestion or percutaneous absorption (Parmeggiana 1983). 2-Methylpyridine was rapidly absorbed and penetrated to the liver, heart, spleen, lungs and muscle during the first 10-20 min following oral administration of 0.5 g/kg to rats (Kupor 1972). The percentage uptake of 2-methylpyridine by rats increased with dosage and its elimination occurred in two phases which also were dose dependent (Zharikov and Titov 1982).
Data on the biotransformation of 2-methylpyridine have been summarized by Williams (1959) and DeBruin (1976). In rabbits and dogs, the compound is oxidized to α-picolinic acid and then conjugated with glycine to form α-picolinuric acid which is excreted in the urine. In hens, it is excreted partially as α-pyridinornithuric acid. About 96% of a 100 mg/kg oral dose of 2-methylpyridine in rats was excreted in the urine as picolinuric acid (Hawksworth and Scheline 1975). There also is evidence that 2-methylpyridine forms an 2-methylated derivative in dogs (Williams 1959). Since 3-methylpyridine is converted to its N-oxide in various species (Gorrod and Damani 1980), it is likely that 2-methyl-pyridine also is similarly oxidized.


UN2313 Picolines, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Biddiscombe and Handley [J Chem Soc 1957 1954] steam distilled a boiling solution of the base in 1.2 equivalents of 20% H2SO4 until about 10% of the base had been carried over, along with non-basic impurities. Excess aqueous NaOH is then added to the residue, the free base is separated, dried with solid NaOH and fractionally distilled. 2-Methylpyridine can also be dried with BaO, CaO, CaH2, LiAlH4, sodium or Linde type 5A molecular sieves. An alternative purification is via the ZnCl2 adduct, which is formed by adding 2-methylpyridine (90mL) to a solution of anhydrous ZnCl2 (168g) and 42mL conc HCl in absolute EtOH (200mL). Crystals of the complex are filtered off, recrystallised twice from absolute EtOH (to give m 118.5-119.5o), and the free base is liberated by addition of excess aqueous NaOH. It is steam distilled, and solid NaOH is added to the distillate to form two layers, the upper one of which is then dried with KOH pellets, stored for several days with BaO and fractionally distilled. Instead of ZnCl2, HgCl2 (430g in 2.4L of hot water) can be used. The complex, which separates on cooling, can be dried at 110o and recrystallised from 1% HCl (to m 156-157o). The hydrochloride has m 78-79o, and the picrate has m 165.5o(from EtOH) and 180o(from H2O). [Beilstein 20 III/IV 2679, 20/5 V 464.]


Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks copper and its alloys.

2-Picoline Preparation Products And Raw materials

Raw materials

Preparation Products

2-Picoline Suppliers

Global( 339)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 CHINA 1365 55
career henan chemical co
+86-371-86658258 CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5882 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58

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View Lastest Price from 2-Picoline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-02 2-Picoline
US $10.00 / KG 1KG 99% 5tons Hebei Guanlang Biotechnology Co., Ltd.
2021-08-26 2-Picoline
US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited
2021-07-13 2-Picoline
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

2-Picoline Spectrum

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