(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione

CAS No.
41451-67-6
Chemical Name:
(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione
Synonyms
Onetine;Onetine【neutral】;(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione;2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione, 4,7-dihydroxy-4-[(1R)-1-hydroxyethyl]-6,7,14-trimethyl-, (1R,4S,6R,7R)-
CBNumber:
CB62272353
Molecular Formula:
C19H29NO8
Molecular Weight:
399.44
MDL Number:
MOL File:
41451-67-6.mol

(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione Properties

Melting point 192-3°C

(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione Chemical Properties,Uses,Production

Description

A hepatotoxic alkaloid from Senecio othonnae M. B., this base is obtained as colourless crystals from MeOH. The alkaloid is dextrorotatory having [α] 20 D + 73° (c 2.5, CHC13). The 12-acetate is identical with Floridanine (q.v.) and the 12: l8-diacetate is Floricaline (q.v.). The flavianate forms colourless crystals from EtOH, m.p. 238-2400 C. The structure has been established from the hydrolysis products, e.g. hydrootonecine and an acid, ClOH1S0 7 , m.p. 142-3°C.

References

Danilova, Koretskaya, Utkin., J. Gen. Chern., USSR, 32, 647 (1962)

(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione Preparation Products And Raw materials

Raw materials

Preparation Products

(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione Suppliers

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(20R)-15,20-Dihydro-12,15α,20-trihydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione Onetine【neutral】 Onetine 2,9-Dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione, 4,7-dihydroxy-4-[(1R)-1-hydroxyethyl]-6,7,14-trimethyl-, (1R,4S,6R,7R)- 41451-67-6