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AMG-47a

AMG-47a Structure
AMG-47a structure
CAS No.
882663-88-9
Chemical Name:
AMG-47a
Synonyms
AMG-47;AMG-47a;CS-1025;AMG-47a/AMG-47;AMG47A; GENETICIN;AMG 47;AMG-47;AMG47;4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamid;4-methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide; 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide;4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide
CBNumber:
CB62518273
Molecular Formula:
C29H28F3N5O2
Molecular Weight:
535.56
MDL Number:
MFCD09970318
MOL File:
882663-88-9.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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AMG-47a Properties

Density 1.324
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 13.23±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

AMG-47a price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25339 AMG 47a ≥98% 882663-88-9 5mg $121 2024-03-01 Buy
Cayman Chemical 25339 AMG 47a ≥98% 882663-88-9 10mg $207 2024-03-01 Buy
Cayman Chemical 25339 AMG 47a ≥98% 882663-88-9 25mg $481 2024-03-01 Buy
Cayman Chemical 25339 AMG 47a ≥98% 882663-88-9 50mg $903 2024-03-01 Buy
TRC A614438 AMG-47a 882663-88-9 5mg $140 2021-12-16 Buy
Product number Packaging Price Buy
25339 5mg $121 Buy
25339 10mg $207 Buy
25339 25mg $481 Buy
25339 50mg $903 Buy
A614438 5mg $140 Buy

AMG-47a Chemical Properties,Uses,Production

Description

AMG 47a is an orally bioavailable inhibitor of Lck, VEGF receptor 2 (VEGFR2/KDR), p38α, and JAK3 (IC50s = 0.2, 1, 3, and 72 nM, respectively). It is selective for these kinases over a panel of additional kinases including SYK, JNK1, and PKAβ (IC50s = 292 to >25,000 nM) but does inhibit Src (IC50 = 2 nM). It decreases IL-2, but not TNF-α, production induced by an anti-CD3 antibody in 50% whole blood and inhibits T cell proliferation in vitro in a mixed lymphocyte reaction assay (IC50 = 30 nM). AMG 47a (10, 30, and 100 mg/kg) has anti-inflammatory activity, decreasing production of IL-2 induced by an anti-CD3 antibody in mice. It also decreases levels of mutant oncogene KRASG12V in HeLa cells in a reporter assay when used at a concentration of 1 μM.

Uses

AMG-47a is a inhibitor of lymphocyte-specific kinase (Lck), which is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells.

References

1. carver j, dexheimer ts, hsu d et al. a high-throughput assay for small molecule destabilizers of the krasoncoprotein. plos one. 2014 aug 5;9(8):e103836.

AMG-47a Preparation Products And Raw materials

Raw materials

Preparation Products

AMG-47a Suppliers

Global( 85)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19639 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Coresyn Pharmatech Co., Ltd. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aceschem Inc. 		58
Aladdin Scientific 		58

View Lastest Price from AMG-47a manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide pictures 2019-12-23 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide
882663-88-9
 US $1.00 / KG 1g Min98% HPLC g/kg /ton Career Henan Chemical Co
AMG-47a AMG-47 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide AMG-47A 4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamid 4-methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide AMG47A; GENETICIN CS-1025 AMG 47;AMG-47;AMG47 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide Benzamide, 4-methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]- AMG-47a/AMG-47 882663-88-9 C29H28F3N5O2 APIs