7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
![7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Structure](CAS/GIF/442666-98-0.gif)
- CAS No.
- 442666-98-0
- Chemical Name:
- 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
- Synonyms
- Anguizole;7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-
- CBNumber:
- CB62589615
- Molecular Formula:
- C17H11ClF2N4O2S
- Molecular Weight:
- 408.81
- MDL Number:
- MFCD03308216
- MOL File:
- 442666-98-0.mol
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0558 | Anguizole 99.48% | 442666-98-0 | 5mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A3182 | Anguizole | 442666-98-0 | 5mg | $159 | 2021-12-16 | Buy |
| ChemScene | CS-0558 | Anguizole 99.48% | 442666-98-0 | 10mg | $216 | 2021-12-16 | Buy |
| ApexBio Technology | A3182 | Anguizole | 442666-98-0 | 10mg | $264 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001852 | ANGUIZOLE 95.00% | 442666-98-0 | 5MG | $279.4 | 2021-12-16 | Buy |
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical Properties,Uses,Production
Biological Activity
anguizole is a selective inhibitor of ns4b with ic50 value of 310 nm [1].ns4b (nonstructural protein 4b) is a viral protein which was found in hepatitis c virus and was a key regulator in hcv replication complex formation. it is reported that ns4b plays a pivotal role in hcv replication via inducing a specific membrane rearrangement and designating membranous web. ns4b-ah2, comprising amino acid 42 to 66, is identified as a major regulator for ns4b oligomerization [2].anguizole is a potent ns4b inhibitor and targets the second amphipathic helix of ns4b (ns4b-ah2). when tested with hcv virus, anguizole treatment significantly disrupted ns4b-ah2-mediated biological functions of ns4b which played an important role in hcv life cycle [3]. in huh7.5 cells transferring a plasmid expressing ns4b fused in frame with gfp, 5μm anguizole treatment (48 hours) altered the distribution of ns4b maf pattern which inhibited hcv life cycle [1].
target
HCV
References
[1]. bryson, p.d., et al., a small molecule inhibits hcv replication and alters ns4b's subcellular distribution. antiviral res, 2010. 87(1): p. 1-8.
[2]. gouttenoire, j., et al., aminoterminal amphipathic alpha-helix ah1 of hepatitis c virus nonstructural protein 4b possesses a dual role in rna replication and virus production. plos pathog, 2014. 10(10): p. e1004501.
[3]. choi, m., et al., a hepatitis c virus ns4b inhibitor suppresses viral genome replication by disrupting ns4b's dimerization/multimerization as well as its interaction with ns5a. virus genes, 2013. 47(3): p. 395-407.
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |