Streptochlorin
- CAS No.
- 120191-51-7
- Chemical Name:
- Streptochlorin
- Synonyms
- SF 2583A;Streptochlorin;Antibiotic SF 2583A;3-(4-Chloro-5-oxazolyl)-1H-indole;4-Chloro-5-(1H-indol-3-yl)oxazole;1H-Indole, 3-(4-chloro-5-oxazolyl)-
- CBNumber:
- CB62650834
- Molecular Formula:
- C11H7ClN2O
- Molecular Weight:
- 218.63908
- MDL Number:
- MFCD18449873
- MOL File:
- 120191-51-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | |||||||||
| NFPA 704 |
|
Streptochlorin price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27605 | Streptochlorin | 120191-51-7 | 1mg | $225 | 2024-03-01 | Buy |
| Cayman Chemical | 27605 | Streptochlorin | 120191-51-7 | 5mg | $844 | 2024-03-01 | Buy |
| Usbiological | 207409 | Streptochlorin | 120191-51-7 | 250ug | $316 | 2021-12-16 | Buy |
| AK Scientific | 3685DF | Streptochlorin | 120191-51-7 | 1mg | $417 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009883 | STREPTOCHLORIN 95.00% | 120191-51-7 | 5MG | $456.05 | 2021-12-16 | Buy |
Streptochlorin Chemical Properties,Uses,Production
Description
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).
Uses
Streptochlorin is an antineoplastic agent and a potential chemotherapeutic agent for treating cholangiocarcinoma.
storage
+4°C
Streptochlorin Preparation Products And Raw materials
Raw materials
Preparation Products
Streptochlorin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
| Shanghai Ruipu Medical Technology Co., Ltd | 15895968936 | 1018762393@qq.com | China | 9968 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |