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BMX-IN-1

BMX-IN-1 structure

CAS No.: 1431525-23-3

Chemical Name:: BMX-IN-1

Synonyms: henyl]-;BMX-IN-1;BMX inhibitor 1;BMX-IN-1 USP/EP/BP;BMX kinase inhibitor;BMX-IN-1 (BMX kinase inhibitor;6]naphthyridin-1(2H)-yl)phenyl)acrylamide;N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1;inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1;N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide

CBNumber:: CB62666602

Molecular Formula:: C29H24N4O4S

Molecular Weight:: 524.59

MDL Number:: MFCD25372042

MOL File:: 1431525-23-3.mol

Last updated:2023-07-12 16:51:57

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BMX-IN-1 Properties

Density	1.397±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
form	solid
pka	7.77±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

BMX-IN-1 price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.05021	BMX-IN-1 - CAS 1431525-23-4 - Calbiochem	1431525-23-3	10mg	$280	2024-03-01	Buy
Cayman Chemical	19165	BMX-IN-1 ≥95%	1431525-23-3	500μg	$32	2024-03-01	Buy
Cayman Chemical	19165	BMX-IN-1 ≥95%	1431525-23-3	1mg	$61	2024-03-01	Buy
Cayman Chemical	19165	BMX-IN-1 ≥95%	1431525-23-3	5mg	$214	2024-03-01	Buy
Tocris	5123	BMX-IN-1 ≥98%(HPLC)	1431525-23-3	5	$160	2021-12-16	Buy

Product number	Packaging	Price	Buy
5.05021	10mg	$280	Buy
19165	500μg	$32	Buy
19165	1mg	$61	Buy
19165	5mg	$214	Buy
5123	5	$160	Buy

BMX-IN-1 Chemical Properties,Uses,Production

Description

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC₅₀ = 8 nM) that targets Cys⁴⁹⁶ in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI₅₀ value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI₅₀s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).

target

BMX Kinase

storage

Store at -20°C

BMX-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

BMX-IN-1 Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	18521735133 18521732826;	market@aladdin-e.com	China	25015	65

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Haoyuan Chemexpress Co., Ltd.	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65

BMX-IN-1 Spectrum

BMX-IN-1(1431525-23-3)¹HNMR

BMX kinase inhibitor N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide henyl]- BMX-IN-1 BMX-INQ: What is BMX-IN Q: What is the CAS Number of BMX-IN Q: What is the storage condition of BMX-IN BMX-IN-1 USP/EP/BP 2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]- BMX inhibitor 1 BMX-IN-1 (BMX kinase inhibitor N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1 BMX KINASE INHIBITOR;N-(2-METHYL-5-(9-(4-(METHYLSULFONAMIDO)PHENYL)-2-OXOBENZO[H][1;6]NAPHTHYRIDIN-1(2H)-YL)PHENYL)ACRYLAMIDE 6]naphthyridin-1(2H)-yl)phenyl)acrylamide inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1 1431525-23-3