1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol
- CAS No.
- 139889-53-5
- Chemical Name:
- 1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol
- Synonyms
- D-threo-PPMP (PPMP);1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol;N-[(1R,2R)-2-hydroxyl-1-(4-monopholinylmethyl)-2-phenylethyl]decanamid;1R,2R-(+)-1-PHENYL-2-PALMITOYLAMINO-3-N-MORPHOLINE-1-PROPANOL;D-THREO-PPMP;Hexadecanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-
- CBNumber:
- CB62719829
- Molecular Formula:
- C29H50N2O3
- Molecular Weight:
- 474.72
- MDL Number:
- MFCD22495353
- MOL File:
- 139889-53-5.mol
- MSDS File:
- SDS
1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol Chemical Properties, Uses, Production
Description
D-threo-PPMP also known as 1R,2R-(+)-1-phenyl-2-palmitoylamino-3-N-morpholine-1-propanol, is a bioactive sphingolipid. It plays a vital role in regulation of ceramide metabolism. D-threo-PPMP influences cytokinesis failure and glycosylation by inhibiting glucosyl ceramide synthase (GCS). D-threo-PPMP also stops acylation reaction by inhibiting the activity of 1-O-acylceramide synthase (1-O-ACS).
Uses
D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production[1][2].
in vitro
On the other hand, D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP), an inhibitor of glucosylceramide synthesis, blocked karyokinesis and reduced cyst production in culture. PPMP also altered the expression of cyst wall protein transcripts in encysting cells._x000D_ _x000D_ Reference: Infect Immun. 2008 Jul;76(7):2939-49. https://pubmed.ncbi.nlm.nih.gov/18426892/
target
D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase.
References
[1] Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. DOI:10.1158/0008-5472.CAN-04-2329
[2] Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. DOI:10.1128/IAI.00116-08
[3] Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8. DOI:10.1016/j.jchromb.2006.03.060
1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol Preparation Products And Raw materials
Raw materials
Preparation Products
1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Auonsi (Shanghai) Biology Technology Co., Ltd. | 400-1107768 15058188853 | 478133536@qq.com | China | 8546 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 18019219489 18901678489 | tech@zzbioco.com | China | 12062 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 | |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Supplier | Advantage |
|---|---|
| Chengdu Huachun Technology Co., Ltd | 60 |
| TargetMol Chemicals Inc. | 58 |
| Auonsi (Shanghai) Biology Technology Co., Ltd. | 58 |
| SHANGHAI ZZBIO CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Creative Enzymes | 58 |
