Bufuralol-(t-butyl-d9) hydrochloride
- CAS No.
- 1173023-51-2
- Chemical Name:
- Bufuralol-(t-butyl-d9) hydrochloride
- Synonyms
- 2H9]-Bufuralol;Bufuralol hydrochloride salt;[2H9]-Bufuralol Hydrochloride;2H9]-Bufuralol hydrochloride salt;Bufuralol-(t-butyl-d9) hydrochloride ;Bufuralol-(t-butyl-d9) hydrochloride
- CBNumber:
- CB62755388
- Molecular Formula:
- C16H24ClNO2
- Molecular Weight:
- 297.82
- MDL Number:
- MFCD09840134
- MOL File:
- 1173023-51-2.mol
| Product description | Number | Pack Size | Price |
| Bufuralol-d9 (hydrochloride) | 29081 | 1mg | $323 |
| Bufuralol-d9Hydrochloride | B689542 | 1mg | $140 |
| Bufuralol-d9Hydrochloride | B689542 | 10mg | $1110 |
| Bufuralol-d9Hydrochloride | 8904BB | 1mg | $457 |
| BUFURALOL-D9-HYDROCHLORIDE 95.00% | BAR0001576 | 1MG | $739.2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| NFPA 704 |
|
Bufuralol-(t-butyl-d9) hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29081 | Bufuralol-d9 (hydrochloride) | 1173023-51-2 | 1mg | $323 | 2024-03-01 | Buy |
| TRC | B689542 | Bufuralol-d9Hydrochloride | 1173023-51-2 | 1mg | $140 | 2021-12-16 | Buy |
| TRC | B689542 | Bufuralol-d9Hydrochloride | 1173023-51-2 | 10mg | $1110 | 2021-12-16 | Buy |
| AK Scientific | 8904BB | Bufuralol-d9Hydrochloride | 1173023-51-2 | 1mg | $457 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BAR0001576 | BUFURALOL-D9-HYDROCHLORIDE 95.00% | 1173023-51-2 | 1MG | $739.2 | 2021-12-16 | Buy |
Bufuralol-(t-butyl-d9) hydrochloride Chemical Properties,Uses,Production
Description
Bufuralol-d9 is intended for use as an internal standard for the quantification of bufuralol by GC- or LC-MS. Bufuralol is a non-selective antagonist of β-adrenergic receptors (β-ARs) that also has partial agonist activity. It decreases mean arterial blood pressure and increases abdominal aortic blood flow in anesthetized cats when administered intravenously at doses of 0.3 and 1 mg/kg. Bufuralol is hydroxylated at the 1'' position by the cytochrome P450 (CYP) isoform CYP2D6 and has been used as a substrate to measure CYP2D6 activity.
Uses
A b-Adrenergic blocker with peripheral vasodilating activity. Antianginal
References
[1] SHIZUO NARIMATSU. Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s[J]. Chirality, 2003, 15 4: 333-339. DOI: 10.1002/chir.10212
[2] TH PRINGLE. Pharmacodynamic and pharmacokinetic studies on bufuralol in man.[J]. British journal of clinical pharmacology, 1986, 22 5: 527-534. DOI: 10.1111/j.1365-2125.1986.tb02931.x
[3] L. BLABER. The effects of bufuralol, a beta-adrenoceptor antagonist with predominant beta 2-adrenoceptor agonistic activity, in the cat and the dog.[J]. Journal of Cardiovascular Pharmacology, 1984, 6 1 1: 165-175. DOI: 10.1097/00005344-198401000-00025
[4] MARK J.I. PAINE . Functional High Level Expression of Cytochrome P450 CYP2D6 Using Baculoviral Expression Systems[J]. Archives of biochemistry and biophysics, 1996, 328 1: Pages 143-150. DOI: 10.1006/abbi.1996.0154
[5] NANCY CHEN. In vitro drug-drug interactions of budesonide: inhibition and induction of transporters and cytochrome P450 enzymes.[J]. Xenobiotica, 2018, 48 6: 637-646. DOI: 10.1080/00498254.2017.1344911
Bufuralol-(t-butyl-d9) hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Bufuralol-(t-butyl-d9) hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Shanghai isotope chemical co.,ltd | 021-51600108 13062666369 | sales@isotopechem.com | China | 5000 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9654 | 58 |
| Xi'an Ruipuyuan Biotechnology Co., Ltd | 18192620610 18192620610 | cs@rpybiotech.com | China | 1425 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | 021-60936350 | scbt@scbt.com | China | 6594 | 58 |
