Bis-PEG6-NHS ester
- CAS No.
- 1526718-98-8
- Chemical Name:
- Bis-PEG6-NHS ester
- Synonyms
- BIS-PEG6-NHS;Di-NHS Ester-PEG6;Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber:
- CB63062418
- Molecular Formula:
- C24H36N2O14
- Molecular Weight:
- 576.55
- MDL Number:
- MFCD24539464
- MOL File:
- 1526718-98-8.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Bis-PEG6-NHS ester price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0107647 | Bis-PEG6-NHSester ≥97.0% | 1526718-98-8 | 100mg | $230 | 2021-12-16 | Buy |
BroadPharm | BP-21681 | Bis-PEG6-NHSester 98% | 1526718-98-8 | 100mg | $250 | 2021-12-16 | Buy |
BroadPharm | BP-21681 | Bis-PEG6-NHSester 98% | 1526718-98-8 | 500mg | $350 | 2021-12-16 | Buy |
ChemScene | CS-0107647 | Bis-PEG6-NHSester ≥97.0% | 1526718-98-8 | 250mg | $400 | 2021-12-16 | Buy |
BroadPharm | BP-21681 | Bis-PEG6-NHSester 98% | 1526718-98-8 | 1g | $460 | 2021-12-16 | Buy |
Bis-PEG6-NHS ester Chemical Properties,Uses,Production
Description
Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Biological Activity
Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
Cleavable
| PEGs
| Alkyl/ether
|
Bis-PEG6-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
View Lastest Price from Bis-PEG6-NHS ester manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-10-24 | Bis-PEG6-NHS ester
1526718-98-8
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
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2024-03-25 | Bis-PEG6-NHS ester
1526718-98-8
|
US $0.00 / g | 5g | >98.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- Bis-PEG6-NHS ester
1526718-98-8
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- Bis-PEG6-NHS ester
1526718-98-8
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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