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KO-947

KO-947 structure

CAS No.: 1695533-89-1

Chemical Name:: KO-947

Synonyms: KO-947;KO947;KO-947;KO 947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-

CBNumber:: CB63168747

Molecular Formula:: C21H17N5O

Molecular Weight:: 355.39

MDL Number:: MFCD31657422

MOL File:: 1695533-89-1.mol

Last updated:2023-05-21 10:59:17

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KO-947 Properties

Boiling point	704.1±60.0 °C(Predicted)
Density	1.354±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
form	A crystalline solid
pka	13.32±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

KO-947 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29213	KO947	1695533-89-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	29213	KO947	1695533-89-1	25mg	$533	2024-03-01	Buy
Cayman Chemical	29213	KO947	1695533-89-1	5mg	$139	2024-03-01	Buy
Cayman Chemical	29213	KO947	1695533-89-1	10mg	$243	2024-03-01	Buy
AK Scientific	8399EM	6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one	1695533-89-1	5mg	$252	2021-12-16	Buy

Product number	Packaging	Price	Buy
29213	1mg	$32	Buy
29213	25mg	$533	Buy
29213	5mg	$139	Buy
29213	10mg	$243	Buy
8399EM	5mg	$252	Buy

KO-947 Chemical Properties,Uses,Production

Description

KO947 is an ERK inhibitor (IC₅₀ = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAF^V600E with an IC₅₀ value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC₅₀s = 50-250 nM for all).

KO-947 Preparation Products And Raw materials

Raw materials

Preparation Products

KO-947 Suppliers

Global( 61)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	6000	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4691	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Nanjing Bicbiotechnology Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58

KO-947 6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one KO947;KO-947;KO 947 7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)- Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947 1695533-89-1