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L-CYSTATHIONINE

CAS No.
56-88-2
Chemical Name:
L-CYSTATHIONINE
Synonyms
L-CYSTATHIONINE;L(+)CYSTATHIONINE;CYSTATHIONINE, L-;L-Cystathionine (P);L-Cystathionine Standard;L-CYSTATHIONINE, >= 98% (TLC);CYSTATHIONINE, L-(DS)(REQUEST QUOTE);(2R,7S)-2,7-Diamino-4-thiaoctanedioic acid;[R]-S-[2-AMINO-2-CARBOXYETHYL]-L-HOMOCYSTEINE;S-[(R)-2-Amino-2-carboxyethyl]-L-homocysteine
CBNumber:
CB6446239
Molecular Formula:
C7H14N2O4S
Molecular Weight:
222.26
MDL Number:
MFCD00036685
MOL File:
56-88-2.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:16

L-CYSTATHIONINE Properties

Melting point 312
alpha D20 +23.7° (1N HCl)
Density 1.430±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. -20°C
solubility Aqueous Acid (Slightly)
form Solid
Boiling point 481.0±45.0 °C(Predicted)
pka 2.08±0.10(Predicted)
color White to Off-White
Merck 13,2807
BRN 2505200
FDA UNII 375YFJ481O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
WGK Germany  3
10-21
HS Code  29309090
NFPA 704
0
2 0

L-CYSTATHIONINE price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C7505 L-Cystathionine ≥98% (TLC) 56-88-2 10mg $108 2024-03-01 Buy
Sigma-Aldrich C7505 L-Cystathionine ≥98% (TLC) 56-88-2 50mg $380 2024-03-01 Buy
Cayman Chemical 16061 L-(+)-Cystathionine ≥98% 56-88-2 5mg $46 2024-03-01 Buy
Cayman Chemical 16061 L-(+)-Cystathionine ≥98% 56-88-2 10mg $74 2024-03-01 Buy
Sigma-Aldrich C7505 L-Cystathionine ≥98% (TLC) 56-88-2 250mg $1520 2024-03-01 Buy
Product number Packaging Price Buy
C7505 10mg $108 Buy
C7505 50mg $380 Buy
16061 5mg $46 Buy
16061 10mg $74 Buy
C7505 250mg $1520 Buy

L-CYSTATHIONINE Chemical Properties,Uses,Production

Description

L-(+)-Cystathionine is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine. L-(+)-Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such as cystathioninuria.

Chemical Properties

White Crystalline Solid

Uses

Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine

Uses

L-Cystathionine has been used in ultra-performance liquid chromatography for the validation of cystathionine and the correlation of its abundance with vertebrate metamorphosis. It has also been used as an inhibitor of sinusoidal GSH (glutathione) carrier to signify that thiol redox state imbalance is associated with the modulation of autophagy in carcinoma cells.

Definition

ChEBI: L-cystathionine is a modified amino acid generated by enzymic means from L-homocysteine and L-serine. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a tautomer of a L-cystathionine dizwitterion.

Biochem/physiol Actions

L-Cystathionine is an intermediate in the biosynthesis of L-cysteine and methionine. It is used as a substrate to differentiate and analyze cystathionine γ-lyase(s). L-Cystathionine is an important non-protein amino acid and is associated with metabolic disorders. In recent studies, L-cystathionine is believed to be the precursor of cyclic imino acid cyclothionine. Cystathioninuria is characterized with imino acid cyclothionine excretion in the urine.

Purification Methods

S,S-Cystathionine is purified by converting it to the HCl salt in 20% HCl and carefully basifying with aqueous NH3 until separation is complete. Filter it off and dry it in a vacuum. It forms prisms from H2O. The dibenzoyl derivative has m 229o (from EtOH). [IR: Greenstein & Winitz Chemistry of the Amino Acids (J Wiley) Vol 3 p2690 1961 and Tallan et al. J Biol Chem 230 707 1958, Synthesis: du Vigneaud et al. J Biol Chem 143 59 1942, Anslow et al. J Biol Chem 166 39 1946.] [Prepn: Weiss & Stekol J Am Chem Soc 73 2497 1951; see also du Vigneaud et al. J Biol Chem 143 60 1942, Biological synthesis: Greenberg Methods Enzymol 5 943 1962, Beilstein 4 IV 3197.]

L-CYSTATHIONINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-CYSTATHIONINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Cystathionine pictures 2019-07-06 L-Cystathionine
56-88-2
US $1.00 / kg 1kg 95%-99% 1000kg Career Henan Chemical Co
CYSTATHIONINE, L- L(+)CYSTATHIONINE L-CYSTATHIONINE L-CYSTATHIONINE, >= 98% (TLC) [R]-S-[2-AMINO-2-CARBOXYETHYL]-L-HOMOCYSTEINE (2S)-2-amino-4-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanylbutanoic acid L-Cystathionine,(R)-S-(2-Amino-2-carboxyethyl)-L-homocysteine (2S)-2-Amino-4-{[(2R)-2-amino-2-carboxyethyl]thio}butanoic acid [R-(R*,S*)]-2-AMino-4-[(2-aMino-2-carboxyethyl)thio]butanoic Acid S-[(2R)-2-AMino-2-carboxyethyl]-L-hoMocysteine CYSTATHIONINE, L-(DS)(REQUEST QUOTE) (2R,7S)-2,7-Diamino-4-thiaoctanedioic acid S-[(R)-2-Amino-2-carboxyethyl]-L-homocysteine L-Homocysteine, S-[(2R)-2-amino-2-carboxyethyl]- L-Cystathionine Standard L-Cystathionine (P) 56-88-2 Amino Acid Library BioChemical Metabolic Libraries Metabolomics Cysteine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Amino Acids 13C, 2H, 15N Amino Acids & Derivatives Intermediates Sulfur & Selenium Compounds