NAcM-OPT
- CAS No.
- 2089293-61-6
- Chemical Name:
- NAcM-OPT
- Synonyms
- NAcM-OPT; NAcM-OPT NEW;Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-;E3 ligating enzyme,Ubiquitin activating enzyme,inhibit,NAcM-OPT,NAE,Ubiquitin conjugating enzyme,NAcMOPT,Ubiquitin ligase,NEDD8-activating Enzyme,E1 activating enzyme,E2 conjugating enzyme,Inhibitor,NAcM OPT,E1/E2/E3 Enzyme
- CBNumber:
- CB64668257
- Molecular Formula:
- C23H29Cl2N3O
- Molecular Weight:
- 434.4
- MDL Number:
- MFCD31693837
- MOL File:
- 2089293-61-6.mol
| Boiling point | 589.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml) |
| form | solid |
| pka | 13.30±0.70(Predicted) |
| color | White |
| Stability | Stable for 1 year as from date of purchase supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
NAcM-OPT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | N633053 | NAcM-OPT | 2089293-61-6 | 10mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BN165240 | NAcM-OPT NEW | 2089293-61-6 | 10mg | $85 | 2021-12-16 | Buy |
| ChemScene | CS-0042279 | NAcM-OPT 98.60% | 2089293-61-6 | 10mg | $90 | 2021-12-16 | Buy |
| AK Scientific | 2411EJ | NAcM-OPT | 2089293-61-6 | 10mg | $164 | 2021-12-16 | Buy |
| ChemScene | CS-0042279 | NAcM-OPT 98.60% | 2089293-61-6 | 50mg | $270 | 2021-12-16 | Buy |
NAcM-OPT Chemical Properties,Uses,Production
Description
NAcM-OPT (2089293-61-6) is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1? It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1
Uses
NAcM-OPT inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.
Definition
ChEBI: 1-Benzyl-1-(1-butyl-4-piperidinyl)-3-(3,4-dichlorophenyl)urea is a member of ureas.
References
1) Scott et al. (2017), Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase; Nat. Chem. Biol., 13 850 2) Scott et al. (2011), N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex; Science, 334 674
NAcM-OPT Preparation Products And Raw materials
Raw materials
Preparation Products
NAcM-OPT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2986 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9242 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |