SMER 3
- CAS No.
- 67200-34-4
- Chemical Name:
- SMER 3
- Synonyms
- SMER 3;SMER3(SMER 3);5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
- CBNumber:
- CB72565931
- Molecular Formula:
- C11H4N4O2
- Molecular Weight:
- 224.18
- MDL Number:
- MFCD00451458
- MOL File:
- 67200-34-4.mol
| Melting point | 283-284 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 437.2±55.0 °C(Predicted) |
| Density | 1.665±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥30mg/mL |
| pka | -8.15±0.20(Predicted) |
| form | powder |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
SMER 3 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7826 | SMER3 ≥98% (HPLC) | 67200-34-4 | 5mg | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | S7826 | SMER3 ≥98% (HPLC) | 67200-34-4 | 25mg | $436 | 2024-03-01 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 67200-34-4 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 67200-34-4 | 10mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 67200-34-4 | 25mg | $199 | 2024-03-01 | Buy |
SMER 3 Chemical Properties,Uses,Production
Description
SMER3 is a selective inhibitor of Skp1-
Uses
SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.
Definition
ChEBI: LSM-42773 is an aromatic ketone.
storage
Store at +4°C
References
1) Aghajanyy et al. (2010), Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor; Nat. Biotechnol., 28 738
SMER 3 Preparation Products And Raw materials
Raw materials
Preparation Products
SMER 3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 17988 | 64 |
| Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23680 | 75 |