ChemicalBook >> CAS DataBase List >>2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- structure

CAS No.: 853953-65-8

Chemical Name:: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Synonyms: GW604714X;5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-;5-(5-(6-(4-Acetylpiperazin-1-yl)-3-nitropyridin-2-yl)-2-fluorobenzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-;2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- ISO 9001：2015 REACH;Inhibitor,mitochondrial respiration,Mitochondrial Metabolism,Parkinson's Disease,MCT1,GW604714X,pyruvate,Alzheimer's Disease,GW-604714X,inhibit,MPC

CBNumber:: CB68106649

Molecular Formula:: C21H18FN5O5S

Molecular Weight:: 471.46

MDL Number:: MFCD33402205

MOL File:: 853953-65-8.mol

Last updated:2023-05-21 10:59:17

Request For Quotation

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Properties

storage temp.	Store at -20°C

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0158684	GW604714X	853953-65-8	5mg	$350	2021-12-16	Buy
ChemScene	CS-0158684	GW604714X	853953-65-8	10mg	$580	2021-12-16	Buy
ChemScene	CS-0158684	GW604714X	853953-65-8	25mg	$1100	2021-12-16	Buy
ChemScene	CS-0158684	GW604714X	853953-65-8	50mg	$1700	2021-12-16	Buy
ChemScene	CS-0158684	GW604714X	853953-65-8	100mg	$2500	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0158684	5mg	$350	Buy
CS-0158684	10mg	$580	Buy
CS-0158684	25mg	$1100	Buy
CS-0158684	50mg	$1700	Buy
CS-0158684	100mg	$2500	Buy

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Chemical Properties,Uses,Production

Biological Activity

GW604714X is a potent and selective inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with a Ki values <0.1 μM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter MCT1, but at concentrations more than four orders of magnitude greater than the MPC[1]. GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with Ki values <0.1 μM in direct measurement of pyruvate transport into rat liver and yeast mitochondria. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their Ki (nM) of 56.0 nM and 0.057 nM for the GW604714X[1].GW604714X inhibits the transport of 0.5 mM [14C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values[1].

References

[1]. K K Yamamoto, et al. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. J Biol Chem. 1992 Feb 5;267(4):2575-81.

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Suppliers

Global( 19)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27644	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9833	58
Jiangsu aikang biomedical research and development co., LTD	025-66110311 13155353615	qzhang@aikonchem.com	China	15527	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Jingmo (Xiamen) Biotechnology Co., Ltd	13621943973 13515979683	sales@jamxmpharmatech.com	China	1080	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	29778	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Dideu Industries Group Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Chaolan Chemical Technology Center	58
Jiangsu aikang biomedical research and development co., LTD	58
DC Chemicals	58
Jingmo (Xiamen) Biotechnology Co., Ltd	58
Beijing Jin Ming Biotechnology Co., Ltd.	58

853953-65-8(2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-)Related Search:

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2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- GW604714X 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- ISO 9001：2015 REACH 5-(5-(6-(4-Acetylpiperazin-1-yl)-3-nitropyridin-2-yl)-2-fluorobenzylidene)thiazolidine-2,4-dione 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Inhibitor,mitochondrial respiration,Mitochondrial Metabolism,Parkinson's Disease,MCT1,GW604714X,pyruvate,Alzheimer's Disease,GW-604714X,inhibit,MPC 853953-65-8