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favipiravir

History Mode of Action A Potential Antiviral for COVID-19?
favipiravir
favipiravir structure
CAS No.
259793-96-9
Chemical Name:
favipiravir
Synonyms
T-705;T-705,T705;Favipiravi;Favipiravir;Favipiravjr;Unii-ew5gl2X7E0;Favipiravir API;T-705 favipiravir;Favipiravir(T-705);favipiravir USP/EP/BP
CBNumber:
CB71055246
Molecular Formula:
C5H4FN3O2
Formula Weight:
157.1
MOL File:
259793-96-9.mol

favipiravir Properties

Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
8.77±0.60(Predicted)
FDA UNII
EW5GL2X7E0

favipiravir price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23384 T-705 ≥98% 259793-96-9 1mg $26 2021-03-22 Buy
Cayman Chemical 23384 T-705 ≥98% 259793-96-9 5mg $98 2021-03-22 Buy
Cayman Chemical 23384 T-705 ≥98% 259793-96-9 10mg $182 2021-03-22 Buy
Cayman Chemical 23384 T-705 ≥98% 259793-96-9 25mg $358 2021-03-22 Buy

favipiravir Chemical Properties,Uses,Production

History

Favipiravir is a broad-spectrum antiviral drug that was cleared by the Drugs Controller General of India (DCGI) last week for “emergency restricted” use among Covid-19 patients. Glenmark will sell the generic favipiravir under the brand name FabiFlu.
Favipiravir was originally developed in the late 1990s by a company that was later purchased by the Japanese firm Fujifilm as part of its transition from the photo business to healthcare. After being tested against a range of viruses, the drug was approved in Japan in 2014 for emergency use against flu epidemics or to treat new strains of influenza.

Mode of Action

Favipiravir inhibits the RNA-dependent RNA polymerase (RdRp) — an enzyme that allows the coronavirus to replicate inside host cells.Inside the cells, favipiravir is converted to favipiravir ribofuranosyl-5′-triphosphate (favipiravir-RTP) by host cells. This molecule then blocks the RdRp enzyme of SARS-CoV-2, the virus that causes Covid-19.According to a statement by Glenmark, favipiravir works only during the earlier stages of the disease, when the viral replication is higher, but the body's immune response has not gone into overdrive.
Metabolism of favipiravir to its triphosphate form occurs in an extracellular environment in a concentration-dependent manner. The vRNA polymerase mistakenly recognizes favipiravir-RTP as a purine nucleotide. This favipiravir-RTP is misincorporated in nascent vRNA, or it may act by binding to conserved polymerase domains, preventing incorporation of nucleotides for vRNA replication and transcription (Jin et al., 2013).

A Potential Antiviral for COVID-19?

Currently, there is not any specific effective antiviral treatment for COVID-19. Although most of the COVID-19 patients have mild or moderate courses, up to 5%–10% can have severe, potentially life threatening course, there is an urgent need for effective drugs. Optimized supportive care remains the mainstay of therapy.
There have been more than 300 clinical trials going on, various antiviral and immunomodulating agents are in various stages of evaluation for COVID-19 in those trials and some of them will be published in the next couple of months. Despite the urgent need to find an effective antiviral treatment for COVID-19 through randomized controlled studies, certain agents are being used all over the world based on either in-vitro or extrapolated evidence or observational studies. The most frequently used agents both in Turkey and all over the world including chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir and remdesivir will be reviewed here .Nitazoxanide and ivermectin were also included in this review as they have recently been reported to have an activity against SARS-CoV-2 in vitro and are licensed for the treatment of some other human infections.

favipiravir Preparation Products And Raw materials

Raw materials

Preparation Products


favipiravir Suppliers

Global( 307)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Senko Biotechnology Co., Ltd.
0086-133 3137 7233
christina@senko-bio.com CHINA 299 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 ericqiao@jnchsd.com CHINA 158 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 4149 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
ENBRIDGE PHARMTECH CO., LTD.
13812269233
0510-83591909 sales@enbridgepharm.com CHINA 216 58
Hebei Binshare New Material Co. Ltd
+8618633865755 +86-86-18633865755
china01@hbbinshare.com CHINA 982 58
Nanjing Fred Technology Co., Ltd.
15380713688 +86-02584696168
Austin@fredchem.cn CHINA 866 58
Handan Tongyi New Material Technology Co., Ltd
+8617330042575
ty003@handantongyi.com CHINA 339 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55

Related articles

  • What is Favipiravir?
  • Favipiravir is a pyrazine carboxamide derivative developed by Toyama Chemical of Japan to act against many RNA viruses. It was....
  • Jul 21,2020

View Lastest Price from favipiravir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-22 favipiravir
259793-96-9
US $65.00 / KG 1KG 99% 20 tons Hanhong Medicine Technology (Hubei) Co., Ltd.
2021-10-21 T-705
259793-96-9
US $1.00 / ASSAYS 1ASSAYS 99.99% 500 Metric Ton/Day Handan Tongyi New Material Technology Co., Ltd
2021-10-20 Favipiravir
259793-96-9
US $20.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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