NOCARDAMINE
- CAS No.
- 26605-16-3
- Chemical Name:
- NOCARDAMINE
- Synonyms
- Nocardamin;NOCARDAMINE;deferrioxamine E;PROFERRIOXAMIN E;Desferrioxamine E;Desferri-ferrioxamine E;Nocardamine (Deferrioxamine E);1,12,23-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone;6,17,28-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexaone;1,6,12,17,23,28-Hexaazacyclotritriacontane-2,5,13,16,24,27-hexone, 1,12,23-trihydroxy-
- CBNumber:
- CB7117055
- Molecular Formula:
- C27H48N6O9
- Molecular Weight:
- 600.7
- MDL Number:
- MFCD08457937
- MOL File:
- 26605-16-3.mol
| Melting point | 192-195° |
|---|---|
| Density | 1.162±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (5 mg/ml) |
| form | solid |
| pka | 8?+-.0.20(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | Q645668975 |
NOCARDAMINE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28745 | Nocardamine | 26605-16-3 | 1mg | $109 | 2024-03-01 | Buy |
| TRC | N634083 | Nocardamine | 26605-16-3 | 1mg | $205 | 2021-12-16 | Buy |
| AK Scientific | 1037CB | Nocardamine | 26605-16-3 | 1mg | $255 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0150-M005 | Nocardamine ≥95%(HPLC) | 26605-16-3 | 5mg | $480 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0019192 | NOCARDAMINE 95.00% | 26605-16-3 | 5MG | $515.55 | 2021-12-16 | Buy |
NOCARDAMINE Chemical Properties,Uses,Production
Description
Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC50 = 9.9 μM). Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.
Uses
Nocardamine is a cyclic siderophore.
Definition
ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.
storage
+4°C
References
Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741 Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34 Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49 Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654 Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292
NOCARDAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
NOCARDAMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52861 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3656 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |