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NSC63925

CAS No.
20261-85-2
Chemical Name:
NSC63925
Synonyms
NSC63925;AKD 1C, S 3466A;5,23-Didemethyl-5,23-diethylnonactin;4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
CBNumber:
CB71251059
Molecular Formula:
C42H68O12
Molecular Weight:
764.98
MDL Number:
MFCD00950779
MOL File:
20261-85-2.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17

NSC63925 Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form film
FDA UNII BEN4Q6B74Y

NSC63925 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20752 Dinactin ≥95% 20261-85-2 1mg $399 2024-03-01 Buy
Cayman Chemical 20752 Dinactin ≥95% 20261-85-2 5mg $998 2024-03-01 Buy
TRC D479728 Dinactin 20261-85-2 2.5mg $3600 2021-12-16 Buy
ApexBio Technology C3454 Dinactin 20261-85-2 5mg $1626 2021-12-16 Buy
American Custom Chemicals Corporation PRO0004291 DINACTIN 95.00% 20261-85-2 1MG $686.7 2021-12-16 Buy
Product number Packaging Price Buy
20752 1mg $399 Buy
20752 5mg $998 Buy
D479728 2.5mg $3600 Buy
C3454 5mg $1626 Buy
PRO0004291 1MG $686.7 Buy

NSC63925 Chemical Properties,Uses,Production

Description

Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K+, NH4+, and Rb+. It is commonly used to study membrane properties. Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces. Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.

Uses

Dinactin is a hydrophobic cyclic ester that inhibits T-cell proliferation induced by IL-2.

Uses

Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. Dinactin has not previously been available for intensive investigation.

in vitro

dinactin inhibited t-cell proliferation induced by il-2, by mab to cd3, and by mabs to cd3 plus α-cd28 with identical dose-response curves. the ic50 was 10–20 ng/ml. dinactin inhibited cytokine production with ic50 values of 10 ng/ml for il-4 and il-5, 30 or 60 ng/ml for interferong or il-2, respectively [3].dinactin inhibited cytokine production through a post-transcriptional mechanism. dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].

References

[1] laprade r, grenier f, pagé-dansereau m, et al. carrier-mediated ion transport in lipid bilayer membranes[j]. canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.
[2] silva l j, crevelin e j, souza w r, et al. streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control botrytis cinerea[j]. phytopathology, 2014, 104(12): 1298-1305.
[3] umland s p, shah h, jakway j p, et al. effects of cyclosporin a and dinactin on t-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[j]. american journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.

NSC63925 Preparation Products And Raw materials

Raw materials

Preparation Products

NSC63925 Suppliers

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BOC Sciences
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MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
NSC63925 5,23-Didemethyl-5,23-diethylnonactin AKD 1C, S 3466A 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)- 20261-85-2