NSC63925
- CAS No.
- 20261-85-2
- Chemical Name:
- NSC63925
- Synonyms
- NSC63925;AKD 1C, S 3466A;5,23-Didemethyl-5,23-diethylnonactin;4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
- CBNumber:
- CB71251059
- Molecular Formula:
- C42H68O12
- Molecular Weight:
- 764.98
- MDL Number:
- MFCD00950779
- MOL File:
- 20261-85-2.mol
- MSDS File:
- SDS
storage temp. | Store at -20°C |
---|---|
solubility | Soluble in DMSO |
form | film |
FDA UNII | BEN4Q6B74Y |
NSC63925 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 20752 | Dinactin ≥95% | 20261-85-2 | 1mg | $399 | 2024-03-01 | Buy |
Cayman Chemical | 20752 | Dinactin ≥95% | 20261-85-2 | 5mg | $998 | 2024-03-01 | Buy |
TRC | D479728 | Dinactin | 20261-85-2 | 2.5mg | $3600 | 2021-12-16 | Buy |
ApexBio Technology | C3454 | Dinactin | 20261-85-2 | 5mg | $1626 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | PRO0004291 | DINACTIN 95.00% | 20261-85-2 | 1MG | $686.7 | 2021-12-16 | Buy |
NSC63925 Chemical Properties,Uses,Production
Description
Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K+, NH4+, and Rb+. It is commonly used to study membrane properties. Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces. Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.
Uses
Dinactin is a hydrophobic cyclic ester that inhibits T-cell proliferation induced by IL-2.
Uses
Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. Dinactin has not previously been available for intensive investigation.
in vitro
dinactin inhibited t-cell proliferation induced by il-2, by mab to cd3, and by mabs to cd3 plus α-cd28 with identical dose-response curves. the ic50 was 10–20 ng/ml. dinactin inhibited cytokine production with ic50 values of 10 ng/ml for il-4 and il-5, 30 or 60 ng/ml for interferong or il-2, respectively [3].dinactin inhibited cytokine production through a post-transcriptional mechanism. dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].
References
[1] laprade r, grenier f, pagé-dansereau m, et al. carrier-mediated ion transport in lipid bilayer membranes[j]. canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.
[2] silva l j, crevelin e j, souza w r, et al. streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control botrytis cinerea[j]. phytopathology, 2014, 104(12): 1298-1305.
[3] umland s p, shah h, jakway j p, et al. effects of cyclosporin a and dinactin on t-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[j]. american journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.
NSC63925 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC63925 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 56533 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8860 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44808 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |