2'-(5''-phosphoribosyl)-5'-adenosine monophosphate
- CAS No.
- 15720-01-1
- Chemical Name:
- 2'-(5''-phosphoribosyl)-5'-adenosine monophosphate
- Synonyms
- 2'-(5-phosphoribosyl)-5'-AMP;2'-(5''-phosphoribosyl)-5'-adenosine monophosphate;5'-Adenylic acid, 2'-O-(5-O-phosphono-β-D-ribofuranosyl)-
- CBNumber:
- CB71307530
- Molecular Formula:
- C15H23N5O14P2
- Molecular Weight:
- 559.32
- MDL Number:
- MOL File:
- 15720-01-1.mol
2'-(5''-phosphoribosyl)-5'-adenosine monophosphate Chemical Properties,Uses,Production
Uses
iso-ADP ribose (isoADPr) is a ligand used for protein nucleic acid modification. iso-ADP ribose is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2].
Definition
ChEBI: An AMP-sugar in which the 2'-hydroxy group of AMP carries a 5-phospho-beta-D-ribosyl substituent. Monomer unit of poly(ADP-Rib) [poly(adenosine diphosphate ribose)].
References
[1] Kewen Peng, et al. Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors. ACS Chem Biol. 2024 Feb 16;19(2):300-307. DOI:10.1021/acschembio.3c00512
[2] Federico Teloni, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016 Feb 18;44(3):993-1006. DOI:10.1093/nar/gkv1383