Chloroprednisone Acetate

Originator

Topilan,Syntex

Manufacturing Process

A suspension of 500 mg 6-α-chlorocortisone (or 6-α-chloro-17-α-hydroxy 21 acetoxy-δ4-pregnene-3,11,20-trione) 25 ml dry tert-butanol, 150 mg selenium oxide and 0.05 ml pyridine were heated to reflux for 70 hours in a nitrogen atmosphere. On cooling the mixture was diluted with 50 ml ethyl acetate, filtered through Cilite and thoroughly washed with ethyl acetate. Ethyl acetate was distilled to a dryness, the dry residue was adsorbed on 25 g of aluminum oxide and eluated with mixture of benzene, ethyl acetate and ether. The obtained fractions were distilled to dryness and recrystallized from acetonehexane. 105 mg of 6α-chloro-17,21-dihydroxypregna-1,4-diene-3,11,20-trione 21-acetate (or 6-α-chloro 17,21-α-hydroxy 21-acetoxy-δ1,4-pregnadiene- 3,11,20-trione) was obtained. MP: 217°-219°C. λmax 238 mμ.

Therapeutic Function

Glucocorticoid

Raw materials

Preparation Products