ChemicalBook >> CAS DataBase List >>Avatrombopag
Avatrombopag
- CAS No.
- 570406-98-3
- Chemical Name:
- Avatrombopag
- Synonyms
- Avatrombopag Base,Avatrombopag;AKR-501;Crenolanib Besylate;Avatrombopag (AKR-501);YM477;E 5501;AS 1670542;AVATROMBOPAG;AKR-501 USP/EP/BP;Avatrombopag Crude
- CBNumber:
- CB72522099
- Molecular Formula:
- C29H34Cl2N6O3S2
- Molecular Weight:
- 649.65
- MDL Number:
- MFCD18633249
- MOL File:
- 570406-98-3.mol
- MSDS File:
- SDS
Last updated:2024-04-01 18:08:31
| Density | 1.440 |
|---|---|
| solubility | DMSO:27.33(Max Conc. mg/mL);42.07(Max Conc. mM) |
| form | A crystalline solid |
| pka | 3.04±0.70(Predicted) |
| FDA UNII | 3H8GSZ4SQL |
| NCI Drug Dictionary | crenolanib besylate |
| ATC code | B02BX08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| NFPA 704 |
|
Avatrombopag price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3397 | Avatrombopag | 570406-98-3 | 5mg | $420 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008153 | AKR-501 95.00% | 570406-98-3 | 5MG | $502.93 | 2021-12-16 | Buy |
| ChemScene | CS-3397 | Avatrombopag | 570406-98-3 | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-3397 | Avatrombopag | 570406-98-3 | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-3397 | Avatrombopag | 570406-98-3 | 100mg | $2520 | 2021-12-16 | Buy |
Avatrombopag Chemical Properties,Uses,Production
Description
Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.
Uses
Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood).
Mechanism of action
Avatrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.
target
TPO receptor
IC 50
IC 50 value is 3.3 nM.
Avatrombopag Preparation Products And Raw materials
Global( 115)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | tracy.li@zisonpharm.com | China | 57 | 58 |
| Shandong Risen-Sun Pharmaceutical Co., Ltd | +86-15552509998 +86-15621883869 | liutf@jewim.com.cn | China | 251 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2141 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27282 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Jinan Ande Pharmaceutical Co.,Ltd. | +8613256107535 | andepharm@163.com | CHINA | 221 | 58 |
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View Lastest Price from Avatrombopag manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-06-13 | Avatrombopag Base,Avatrombopag
570406-98-3
|
US $0.00-0.00 / kg | 1kg | ＞99% by HPLC | 5kg/Month | Zison Pharmaceutical (Shandong) Co., Ltd. | |
 |
2024-04-02 | Avatrombopag (AKR-501)
570406-98-3
|
US $0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2023-04-11 | Avatrombopag
570406-98-3
|
US $0.00-0.00 / kg | 1kg | 99% | 100kg | Nanjing Kaitian Chemical Co., LTD |
-
- Avatrombopag Base,Avatrombopag
570406-98-3
- US $0.00-0.00 / kg
- ＞99% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
-
- Avatrombopag (AKR-501)
570406-98-3
- US $0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Avatrombopag
570406-98-3
- US $0.00-0.00 / kg
- 99%
- Nanjing Kaitian Chemical Co., LTD
AVATROMBOPAG
AS 1670542
E 5501
4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-
Avatrombopag(AS1670542)
1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo
1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid
1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid
AKR-501; YM477; E5501; AS 1670542
YM477
AKR-501 USP/EP/BP
1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2
Crenolanib Besylate
AKR-501
Avatrombopag (AKR-501)
Avatrombopag Base,Avatrombopag
4- (2- (6- (4-carboxypyridine-1-yl) - (5-chloronicotinamide) -4- (4-chlorothienyl-2-yl) thiazol-5-yl) -1-cyclohexylpiperazine
1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid (Avatrombopag Impurity)
1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
Avatrombopag Monomer
Avatrombopag Crude
570406-98-3
C29H34Cl2N6O3S2
Intermediate
API