FGF-19, HUMAN
- CAS No.
- Chemical Name:
- FGF-19, HUMAN
- Synonyms
- FGFJ;FGF19;UNQ334;PRO533;HUMAN FGF-19;FGF-19, HUMAN;HUMAN FIBROBLAST GROWTH FACTOR-19;FIBROBLAST GROWTH FACTOR-19, HUMAN;Recombinant Human FGF-19 Protein, His Tag
- CBNumber:
- CB7253265
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03792329
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| FGF-19 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE) | SRP4542 | 25μg | $368 |
| FGF19 | 382865 | 96Tests | $729 |
| FGF19 | orb529261 | 10μg | $397.8 |
FGF-19, HUMAN price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP4542 | FGF-19 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE) | 25μg | $368 | 2023-06-20 | Buy | |
| Usbiological | 382865 | FGF19 | 96Tests | $729 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb529261 | FGF19 | 10μg | $397.8 | 2021-12-16 | Buy |
FGF-19, HUMAN Chemical Properties,Uses,Production
Description
FGF19 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 195 amino acids and having a molecular mass of 21.8 kDa.
The FGF-19 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
The FGFs are a family of more than 20 small (~17–26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response.
FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. The overexpression of a dominant negative form of FGFR-1 in ? cells leads to diabetes in mice, which thus implies that proper FGF signaling is required for normal ? cell function and glycemia maintenance. FGFR-2 appears to be a key molecule during pancreatic development. Moreover, FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis.
FGF-19, has been shown to cause resistance to diet-induced obesity and INS desensitization and to improve INS, glucose, and lipid profiles in diabetic rodents. Since these effects, at least in part, are mediated through the observed changes in metabolic rates, FGF-19 can be considered as a regulator of energy expenditure.
FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.
FGF-19, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
FGF-19, HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10308 | 58 |
| Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-59178156 17002132182 | 3146474380@qq.com | China | 10000 | 58 |
| Biolab Reagents | 65279366 18108604356 | products@biolabreagent.com | China | 9868 | 58 |
| ACROBiosystems | 13121935750 | jiaxin.zhao@acrobiosystems.com | China | 1361 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 6174 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Beijing Biosynthesis Biotechnology Co Ltd | 400-9019800 | sales@bioss.com.cn | China | 6102 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
| ProSpec Tany TechnoGene Ltd | 972-8947-1175 | info@prospecbio.com | China | 6874 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 6078 | 58 |
