ChemicalBook >> CAS DataBase List >>Begacestat

Begacestat

CAS No.
769169-27-9
Chemical Name:
Begacestat
Synonyms
GSI-953;Begacestat;Begacestat(GSI-953);GSI-953 DISCONTINUED;Begacestat (Synonyms: GSI-953);5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxyMethyl)-2-(trifluoroMethyl)propyl]-2-thiophenesulfonaMide;2-Thiophenesulfonamide, 5-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-;5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide;(2S)-S-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-hydroxy-N-Methyl-3-(trifluoroMethyl)butane-2-sulfonaMido
CBNumber:
CB72535664
Molecular Formula:
C9H8ClF6NO3S2
Molecular Weight:
391.74
MDL Number:
MFCD18782675
MOL File:
769169-27-9.mol
MSDS File:
SDS
Last updated:2023-05-18 11:30:58

Begacestat Properties

Melting point 153-155°C
Boiling point 355℃
Density 1.642
Flash point 169℃
storage temp. 2-8°C
solubility DMSO: ≥15mg/mL
form powder
pka 8.16±0.50(Predicted)
color white to tan
FDA UNII 3666C56BBU

SAFETY

Risk and Safety Statements

WGK Germany  3

Begacestat price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0187 GSI-953 ≥98% (HPLC) 769169-27-9 5mg $132 2024-03-01 Buy
Sigma-Aldrich PZ0187 GSI-953 ≥98% (HPLC) 769169-27-9 25mg $516 2024-03-01 Buy
Cayman Chemical 27916 Begacestat 769169-27-9 1mg $56 2024-03-01 Buy
Cayman Chemical 27916 Begacestat 769169-27-9 5mg $124 2024-03-01 Buy
Tocris 4283 Begacestat ≥98%(HPLC) 769169-27-9 10 $212 2021-12-16 Buy
Product number Packaging Price Buy
PZ0187 5mg $132 Buy
PZ0187 25mg $516 Buy
27916 1mg $56 Buy
27916 5mg $124 Buy
4283 10 $212 Buy

Begacestat Chemical Properties,Uses,Production

Uses

Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.

Begacestat Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94838 76
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
shanghai cooperpharm co.,LTD . +86-021-58975553 sales@cooperpharm.com China 1210 56
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 17993 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai BetterBioChem Co., Ltd. +86-18017644823 sales@betterbiochem.com China 325 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55936 58
Aishilun biotechnology (Shanghai) co., LTD 021-50676523 18019098996 info@acelybio.com China 3967 58
Begacestat Begacestat(GSI-953) GSI-953 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxyMethyl)-2-(trifluoroMethyl)propyl]-2-thiophenesulfonaMide (2S)-S-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-hydroxy-N-Methyl-3-(trifluoroMethyl)butane-2-sulfonaMido 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide 2-Thiophenesulfonamide, 5-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]- Begacestat (Synonyms: GSI-953) GSI-953 DISCONTINUED 769169-27-9 C9H8ClF6NO3S2 Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals Sulfur & Selenium Compounds