(R)-MG132
- CAS No.
- 1211877-36-9
- Chemical Name:
- (R)-MG132
- Synonyms
- D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-;NSC60585;NSC 60585;MG-132(R);(R)-MG132;NSC-60585;MG-132(S,R,S);Z-Leu-D-leu-leu-al;(S,R,S)-(-)-MG-132;Cbz-L-leu-D-leu-L-leu-H
- CBNumber:
- CB72589829
- Molecular Formula:
- C26H41N3O5
- Molecular Weight:
- 475.62
- MDL Number:
- MFCD28580122
- MOL File:
- 1211877-36-9.mol
- MSDS File:
- SDS
(R)-MG132 price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1135 | MG-132(R) ≥95% (HPLC) | 1211877-36-9 | 5mg | $482 | 2024-03-01 | Buy |
Sigma-Aldrich | M8699 | (R)-MG132 | 1211877-36-9 | 1MG | $180 | 2023-06-20 | Buy |
Cayman Chemical | 13697 | (R)-MG132 ≥98% | 1211877-36-9 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 13697 | (R)-MG132 ≥98% | 1211877-36-9 | 5mg | $202 | 2024-03-01 | Buy |
Cayman Chemical | 13697 | (R)-MG132 ≥98% | 1211877-36-9 | 10mg | $341 | 2024-03-01 | Buy |
(R)-MG132 Chemical Properties,Uses,Production
Description
The ubiquitin-
Uses
(R)-MG-132 is a potent, reversible and selective tripeptide aldehyde proteasome inhibitor.
Uses
(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.
Definition
ChEBI: D-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]- is a peptide.
Biochem/physiol Actions
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.
storage
Store at -20°C
(R)-MG132 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 854 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |